Zhen XIE


Zhen XIE


Tsinghua Information Science and Technology Lab


Principle Investigator


Education and Work Experience

2011.12 - Present, Professor, Global Expert-1000 Plan (Young Talent Group), Tsinghua University
2010.07 - 2011.12, Postdoctoral Associate, Department of Biological Engineering, Computer Science and Artificial Intelligence Lab, MIT
2006.10 - 2010.07, Postdoctoral Fellow, FAS Center for Systems Biology, Harvard University
2002.01 - 2006.12, Ph.D., Department of Biological Sciences, University of Nevada Las Vegas
1998.09 - 2001.07, M.S., Department of Horticulture, Shandong Agricultural University
1994.09 - 1998.07, B.S., Department of Horticulture, Shandong Agricultural University


Research Area

Construction of parts and motifs for synthetic biology research
Automation for gene synthesis and genetic circuit assembly
Genetic circuit engineering for gene therapy and cell-based therapy
Integrative biomolecular sensing and processing for cellular automation


Selected Publication

Li Y, Jiang Y, Chen H, Lian W, Li Z, Weiss R, Xie Z. Modular construction of mammalian gene circuits using TALE transcriptional repressors. Nat Chem Biol. 2015, 11:207-13.

Schmid-Burgk JL, Xie Z, Frank S, Virreira-Winter S, Mitschka S, Kolanus W, Murray A, Benenson Y. Rapid hierarchical assembly of medium-size DNA cassettes. Nucleic Acids Res. 2012, 40:e92.

Leisner M, Bleris L, Lohmueller J, Xie Z and Benenson Y. MicroRNA circuits for transcriptional logic. Methods Molecular Biology. 2012, 813:169-86.

Xie Z., Wroblewska L, Prochazka L, Weiss R, Benenson Y. Multi-input RNAi-based logic circuit for identification of specific cancer cells. Science.2011, 333:1307-11

Bleris L, Xie Z, Glass D, Adadey A, Sontag E, Benenson Y. Synthetic incoherent feed-forward circuits show adaptation to the amount of their genetic template. Molecular Systems Biology .2011, 7:519.

Leisner M, Bleris L, Lohmueller J, Xie Z, Benenson Y. Rationally designed logic integration of regulatory signals in mammalian cells. Nature Nanotechnology. 2010, 5: 666-70.

Xie Z, Liu SJ, Bleris L, Benenson Y. Logic integration of mRNA signals by an RNAi-based molecular computer. Nucleic Acids Research. 2010, 38: 2692-2701.


Tsinghua Information Science and Technology Lab


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