国际计算生物学会（International Society for Computational Biology，简称ISCB）官网近日公布了今年新一届的会士名单，中国生物工程学会常务理事、计算生物学与生物信息学专业委员会常务副主任、清华大学自动化系教授张学工入选，成为首位入选的中国学者。
ISCB成立于1997年，是生物信息学与计算生物学领域最大规模的国际学术组织，旨在通过计算促进对生命系统的理解并促进全球科学进步。ISCB 会士旨在表彰在计算生物学和生物信息学领域做出重大贡献的杰出成员，选择的标准是基于这些学者所做出的科学贡献的重要性。本年度共有12位科学家入选。
ISCB官网评价：清华大学张学工教授在发展转录组和RNA-seq数据的计算分析方法（如DEGseq、DEsingle、SCRL和scFly等）方面做出了重要贡献，建立了有影响力的研究生项目，培养了大量学生，推动了中国计算生物学和生物信息学的发展。
此外，张学工教授于2019年7月当选为国际计算生物学会理事（Board member）。目前ISCB共有24名理事，张学工教授是唯一来自中国的理事，同时也是目前唯一的华人理事。
ISCB官网新闻链接：https://www.iscb.org/iscb-news-items/4250-2020-feb19-iscb-congratulates-2020-class-fellows
张数一
清华大学 药学院
博士 助理教授
教育经历
2005年-2009年 清华大学 本科
2009年-2015年 宾夕法尼亚州立大学 博士
2015年-2019年 麻省理工学院 博士后
2019至今 清华大学药学院 助理教授
研究方向
合成生物学作为生命科学和工程科学相结合的前沿交叉学科，在医药、环境、健康等领域都有巨大的潜在应用价值。合成生物学的主要研究目标是用工程化的方法设计复杂可控的生命系统。张数一实验室长期致力于合成生物学关键领域的研究，聚焦在代谢通路、能量摄取、调控网络等领域，相关研究成果发表在Science，Nature Biotechnology，Nature Microbiology，Nucleic Acids Research，Metabolic Engineering等顶级学术期刊。针对这些合成生物学的关键方向，目前课题组侧重在优良蛋白质元件的计算机辅助从头理性设计、自动化平台赋能的高通量表征、连续定向进化系统辅助的快速精准优化等，以及将这些设计和改造后的蛋白质元件有机耦合基因线路，搭建生物系统，有效地应用于疾病诊断和治疗等领域。
科学贡献
1，代谢通路：
研究成果解决了困扰蓝细菌科学界接近半个世纪的有关三羧酸循环的难题，彻底改变了科学界对蓝细菌中心代谢通路的认识。这个研究成果已被世界经典教科书《Brock Biology of Microorganisms》第14版第3章作为封面收录。
2，能量摄取：
我们与合作者共同发现了能利用远红光的光合系统，拓展了光合作用的潜能，被英国皇家科学院院士 Bill Rutherford教授称为改变教科书式的新发现。
3，调控网络：
实现了复杂调控网络的自动化设计，编辑细胞进行逻辑运算，成功构建了能显示7段数码管的工程菌。自动化设计并改进了基于CRISPR系统的调控网络，实现了肠道微生物的基因回路运算。
荣誉和奖励
国家高层次人才计划青年项目
国家优秀自费留学生奖
宾夕法尼亚州立大学优秀博士论文奖
代表性论文
1. Shuyi Zhang and Donald A. Bryant. (2011). The tricarboxylic acid cycle in cyanobacteria. Science, 334, 1551-1553, DOI: 10.1126/science.1210858
2. Kenchappa G. Kumaraswamy, Xiao Qian, Tiago Guerra, Shuyi Zhang, Donald A. Bryant and Charles G. Dismukes. (2013). Reprogramming the glycolytic pathway for increased hydrogen production in cyanobacteria: metabolic engineering of NAD+-dependent GAPDH. Energy & Environmental Science, 6(12):3722-3731, DOI: 10.1039/C3EE42206B
3. Shuyi Zhang, Gaozhong Shen, Zhongkui Li, John H. Golbeck and Donald A. Bryant. (2014). Vipp1 is essential for the biogenesis of Photosystem I but not thylakoid membranes in Synechococcus sp. PCC 7002. Journal of Biological Chemistry, 289(23), 15904-15914, DOI: 10.1074/jbc.M114.555631
4. Fei Gan, Shuyi Zhang, Nathan C. Rockwell, Shelley S. Martin, Clark J. Lagarias and Donald A. Bryant. (2014) Extensive remodeling of a cyanobacterial photosynthetic apparatus in Far-Red light. Science, 345, 1312-1317, DOI: 10.1126/science.1256963
5. Hans C. Bernstein, Allan Konopka, Matthew R. Melnicki, Eric A. Hill, Leo A. Kucek, Shuyi Zhang, Gaozhong Shen, Donald A. Bryant and Alexander S. Beliaev. (2014) Effect of mono- and dichromatic light quality on growth rates and photosynthetic performance of Synechococcus sp. PCC 7002. Frontiers in Microbiology, 5, 488, DOI: 10.3389/fmicb.2014.00488
6. Shuyi Zhang and Donald A. Bryant. (2014) Learning new tricks from an old cycle: the TCA cycles of cyanobacteria, algae and plants. Perspectives in Phycology, 2, 73-86,Invited review article, DOI: 10.1127/pip/2014/0016
7. Shuyi Zhang and Donald A. Bryant. (2015) Biochemical validation of the the glyoxylate cycle in the cyanobacterium Chlorogloeopsis fritschii PCC 9212, Journal of Biological Chemistry290 (22), 14019-14030, DOI: 10.1074/jbc.M115.648170
8. Shuyi Zhang, Yang Liu and Donald A. Bryant. (2015) Metabolic engineering of Synechococcus sp. PCC 7002 to produce poly-3-hydroxybutyrate and poly-3-hydroxybutyrate-co-4-hydroxybutyrate, Metabolic Enginneering, 32, 174-183, DOI:10.1016/j.ymben.2015.10.001
9. Xiao Qian, Kenchappa G. Kumaraswamy, Shuyi Zhang, Colin Gates, Donald A. Bryant and Charles G. Dismukes. (2015) Inactivation of nitrate reductase alters metabolic branching of carbohydrate fermentation in the cyanobacterium Synechococcus sp. strain PCC 7002. Biotechnology & Bioengineering, 113(5):979-988, DOI: 10.1002/bit.25862
10. Anagha Krishnan, Shuyi Zhang, Yang Liu, Kinan A Tadmori, Donald A Bryant and G Charles Dismukes (2015) Consequences of ccmR deletion on respiration, fermentation and H2 metabolism in cyanobacterium Synechococcus sp. PCC 7002. Biotechnology & Bioengineering, 113(7):1448-1459, DOI:
11. Shuyi Zhang, Xiao Qian, Shannon Chang, G Charles Dismukes and Donald A Bryant (2016) Natural and synthetic variants of the tricarboxylic acid cycle in cyanobacteria: introduction of the GABA shunt into Synechococcus sp. PCC 7002. Frontiers in Microbiology, 7, 1972, DOI:
12. Shuyi Zhang and Christopher A. Voigt. (2018) Engineered dCas9 with reduced toxicity in bacteria: implications for genetic circuit design. Nucleic Acids Research,gky884, DOI:10.1093/nar/gky884
13. Kenchappa G Kumaraswamy, Anagha Krishnan, Gennady Ananyev, Shuyi Zhang, Donald A. Bryant and G Charles Dismukes. (2019) Crossing the Thauer limit: Rewiring Cyanobacterial Metabolism to Maximize Fermentative H2Energy & Environmental Science, 12, 1035-1045, DOI:
14. Jonghyeon Shin, Shuyi Zhang, Bryan S. Der, Alec A.K. Nielsen, and Christopher A. Voigt. (2020) Programming Escherichia coli to function as a digital display. MolecularSystemsBiology,16:e9401, DOI: 10.15252/msb.20199401. Highlighted as Cover Article.
15. Mao Taketani, Jianbo Zhang, Shuyi Zhang, Alexander J. Triassi, Yu-Ja Huang, Linda G. Griffith & Christopher A. Voigt. Bacteroides thetaiotaomicron. Nature Biotechnology, 38, 962–969, DOI: 10.1038/s41587-020-0468-5
16. Ye Chen, Shuyi Zhang, Eric M. Young, Timothy S. Jones, Douglas Densmore & Christopher A. Voigt (2020) Genetic circuit design automation for yeast. Nature Microbiology, 5, 1349–1360, DOI: 10.1038/s41564-020-0757-2
联系方式
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李雪明
清华大学 研究员
博士生导师
教育经历
1998-2002年 北京科技大学 材料物理系 学士
2002-2005年 北京科技大学 材料物理与化学系 硕士
2005-2009年 中科院物理研究所 凝聚态物理 博士
2009-2013年 加州大学旧金山分校 博士后
2014年至今 清华大学生命科学学院，清华-北大生命科学联合中心，北京结构生物学高精尖中心 研究员
研究方向
主要从事冷冻电子显微学理论和方法研究，着重于开发和利用最新的电子显微学技术，以提高冷冻电子显微学三维重构的分辨率到原子水平；同时致力于将电子显微学应用到结构生物学研究中去，以解决与结构相关的重要生物学问题。在生物方面，从事细菌外膜分泌系统的结构与功能研究。
科学贡献
所获荣誉
2015. Youth One-Thousand Program by State Council of China青年千人)
2015. QiuShi Award for Excellent Young Scientis（求是杰出青年学者）
2016. the National Science Fund for Excellent Young Scholars（优青）
代表性论文
1. Li Wang#, Heng Zhou#, Mingmin Zhang#, Wenhao Liu#, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li*, Bailong Xiao*, Structure and mechanogating of the mammalian tactile channel PIEZO2, Nature, 2019, 573, 225-229
2. Heng zhou#, Feng Luo#, Zhipu Luo#, Dan Li, Cong Liu*, Xueming Li*, Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules, Analytical Chemistry, 2019, 91, 10996-11003
3. Meijing Li#, Xian Xia#, Yuanyuan Tian#, Qi Jia#, Xiaoyu Liu#, Ying Lu, Ming Li*, Xueming Li*, and Zhucheng Chen*, Mechanism of DNA translocation underlying chromatin remodeling by Snf2, Nature, 2019, 567, 409-413
4. Heng Zhou#, Zhipu Luo#, Xueming Li*, Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction, Journal of Structural Biology, 2019, 205, 59-64
5. Meng Yin#, Zhaofeng Yan#, Xueming Li*, Architecture of type VI secretion system membrane core complex, Cell Research, 2019, 29, 251-253
6. Mingxu Hu#, Hongkun Yu#, Kai Gu#, Zhao Wang, Huabin Ruan, Kunpeng Wang, Siyuan Ren, Bing Li, Lin Gan, Shizhen Xu, Guangwen Yang*, Yuan Shen*, Xueming Li*, A particle-filter framework for robust cryoEM 3D reconstruction, Nature Methods, 2018, 15, 1083-1089
7. Yaowang Li#, Chunyu Zhao#, Feng Luo#, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li*, Cong Liu* and Xueming Li*, Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy, Cell Research, 2018, 28, 897-903.
8. Meng Yin#, Zhaofeng Yan#, Xueming Li, Structural insight into the assembly of the Type II Secretion System Pilotin-Secretin Complex from enterotoxigenic Escherichia coli, Nature Microbiology, 2018, 3,581-587.
9. Feng Luo#, Xinrui Gui#, Heng Zhou#, Jinge Gu, Yichen Li, Xiangyu Liu, Minglei Zhao, Dan Li*, Xueming Li*, Cong Liu*, Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation, Nature Structural & Molecular Biology, 2018, 25, 341–346
10. Qiancheng Zhao#, Heng Zhou#, Shaopeng Chi#, Yanfeng Wang#, Jianhua Wang, Jie Geng, Kun Wu, Wenhao Liu, Tingxin Zhang, Meng-Qiu Dong, Jiawei Wang, Xueming Li*, Bailong Xiao*. Structure and mechanogating mechanism of the Piezo1 channel. Nature, 2018, 554, 487-492.
11. Xiaoyuan Zhou#, Minghui Li#, Deyuan Su, Qi Jia, Huan Li, Xueming Li*& Jian Yang*,Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states, Nature Structural & Molecular Biology, 2017, 24, 1146-1154
12. Zhaofeng Yan#, Meng Yin#, Dandan Xu, Yongqun Zhu*, Xueming Li*, Structural Insights into Secretin Translocation Channel in Type II Secretion System, Nature Structure & Molecular Biology, 2017, 24, 177-183.
13. Minghui Li#, Xiaoyuan Zhou#, Shu Wang, Ye Gong, Deyuan Su, Huan Li, Xueming Li*, and Jian Yang*, Cryo-EM structure of a eukaryotic cyclic nucleotide-gated channel, Nature, 2017, 542, 60-65.
14. Xiaoyu Liu#, Meijing Li#, Xian Xia#, Xueming Li*, and Zhucheng Chen*,Mechanism of chromatin remodeling revealed by the Snf2-nucleosome structure, Nature, 2017, 544, 440-445.
15. Feng Wang#, Huichao Gong#, Gaochao Liu,# Meijing Li , Chuangye Yan, Tian Xia*, Xueming Li*, Jianyang Zeng*, DeepPicker: a Deep Learning Approach for Fully Automated Particle Picking in Cryo-EM, Journal of Structural Biology, 2016(195), 325-336
16. Xueming Li, Shawn Zheng, David A. Agard, Yifan Cheng, Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage, Journal of Structural Biology, 192, 174-178, 2015
17. Soyeon Park#, Xueming Li#, Homin Kim#, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs*, Yifan Cheng*, and Daniel Finley*, Reconfiguration of the proteasome during chaperone-mediated assembly, Nature, 497, 512-516, 2013. (*co-first author)
18. Xueming Li, Paul Mooney, Shawn Zheng, Chris Booth, Michael B. Braunfeld, Sander Gubbens, David A. Agard* and Yifan Cheng*, Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM, Nature Methods, 10, 584-590, 2013.
¶ Featured in Nature Methods News and Views: Robert M. Glaeser (2013) Stroboscopic imaging of macromolecular complexes. Nature Methods 10, 475-476.
¶ Featured in Nature Methods: Method of the Year 2013.
¶ Featured in Science: Martin T.J. Smith and John L. Rubinstein (2014), Beyond blob-ology: Advanced cryo-electron microscopy yields high-resolution structures of proteins, Science 345, 617
19. Xueming Li, Shawn Zheng, Kiyoshi Egami,David A. Agard*, Yifan Cheng*, Influence of electron dose rate on electron counting images recorded with the K2 camera, J Struct. Biol., 184, 251-260, 2013.
20. Xueming Li, Nikolaus Grigorieff, Yifan. Cheng*, GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors, J Struct Biol., 172, 407-12, 2010
办公室电话：62782271
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the-university-of-manchester-and-tsinghua-university-beijing-have-launched-a-new-dual-degree-phd-programme-in-synthetic-and-systems-biology
The programme builds on the collaborative agreement signed between the Manchester Institute of Biotechnology and Tsinghua University’s Centre for Synthetic and Systems Biology in 2016.
Students will benefit from the world-class academic supervision, facilities and research infrastructure of these two globally renowned universities.
Professor George Guoqiang Chen, the Programme Director of Tsinghua University, said: “This Tsinghua-Manchester dual degree PhD programme will provide unique opportunities for students to experience various research environments of both Universities, to learn great sciences across national borders and to become more culturally open. More importantly, the students will exploit complementary strengths of both sites. We expect students graduating from this programme to be much more competitive in the global market.”
The University of Manchester and Tsinghua University have had an ongoing relationship for many years, established initially in 2007 during the tenures of Professor Alan Gilbert and Professor Gu Binglin and formalised in January 2018 when the presidents of the two universities, Professor Dame Nancy Rothwell and Professor Yong Qiu, signed a Memorandum of Understanding.
Dr Neil Dixon, from Manchester’sDepartment of Chemistryhas been appointed Programme Director and will provide the academic leadership for its implementation and development. Speaking at the launch of the programme, Dr Dixon said: “This promises to be a fantastic programme and will provide a unique educational experience for the next generation of scientists. The strengths of Manchester and Tsinghua together will provide an excellent environment for PhD students to grow and blossom. The international outlook of the programme will provide the students with the skill set to address current and future global challenges.”
For more than ten years numerous research collaborations have been initiated, especially in Science and Engineering. The launch of this initiative represents a significant milestone in the development of the broader relationship between The University of Manchester and Tsinghua University.
Professor Martin Schröder, Vice President of The University of Manchester and Dean of theFaculty of Science and Engineeringstates: “The area of industrial biotechnology, embracing synthetic and systems biology, is a research beacon for The University of Manchester, representing a world-leading interdisciplinary activity with major funding and outstanding outputs and impact. This new collaboration with Tsinghua University will enable new routes to translation of research discoveries to the market-place to the benefit of all, and will also forge an important new relationship between the two Universities.”
The recruitment process is now underway and the first cohort of students will commence their studies from September 2020.
吴赴清
清华大学 副研究员
教育经历
1999.09-2003.07，西南农业大学 学士
2003.09-2009.06，中国农业大学 博士
2009.07-2012.12，中国农业科学院作科所，助理研究员
2013.01-2018.07，中国农业科学院作科所，副研究员
2018.08-至今，清华大学生命学院，副研究员
研究方向
（1）聚羟基脂肪酸酯医学应用研究
（2）嗜盐微生物抗盐碱机制解析及其应用
代表性论文
1. Ma W#, Wu F#, Sheng P, Wang X, Zhang Z, Zhou K, Zhang H, Hu J, Lin Q, Cheng Z, Wang J, Zhu S, Zhang X, Guo X, Wang H, Wu C, Zhai H, Wan J. The LBD12-1 Transcription Factor Suppresses Apical Meristem Size by Repressing Argonaute 10 Expression. Plant Physiol. 2017 Jan;173(1):801-811.
2. Liu J, Chen J, Zheng X, Wu F, Lin Q, Heng Y, Tian P, Cheng Z, Yu X, Zhou K, Zhang X, Guo X, Wang J, Wang H, Wan J. GW5 acts in the brassinosteroid signaling pathway to regulate grain width and weight in rice. Nature Plants, 2017, 3, 17043
3. Wang J#, Wu F#, Zhu S, Xu Y, Cheng Z, Wang J, Li C, Sheng P, Zhang H, Cai M, Guo X, Zhang X, Wang C, Wan J. Overexpression of OsMYB1R1-VP64 fusion protein increases grain yield in rice by delaying flowering time. FEBS Lett. 2016 Oct;590(19):3385-3396.
4. Sheng P#, Wu F#, Tan J, Zhang H, Ma W, Chen L, Wang J, Wang J, Zhu S, Guo X, Wang J, Zhang X, Cheng Z, Bao Y, Wu C, Liu X, Wan J. CONSTANS-like transcriptional activator, OsCOL13, functions as a negative regulator of flowering downstream of OsphyB and upstream of Ehd1 in rice. Plant Mol Biol. 2016 Sep;92(1-2):209-22.
5. Lin Q#, Wu F#, Sheng P, Zhang Z, Zhang X, Guo X, Wang J, Cheng Z, Wang J, Wang H, Wan J. The SnRK2-APC/CTE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathway in plants. Nature commun, 2015, 14, 6:7981 | DOI: 10.1038/ncomms8981 |
6. Wu F#, Sheng P#, Tan J†, Chen X, Lu G, Ma W, Heng Y, Lin Q, Zhu S, Wang J, Wang J, Guo X, Zhang X, Lei C, Wan J. Plasma membrane receptor-like kinase leaf panicle 2 acts downstream of the DROUGHT AND SALT TOLERANCE transcription factor to regulate drought sensitivity in rice. J Exp Bot. 2015 Jan;66(1):271-81.
7. Lu G#, Wu F#, Wu W, Wang H, Zheng X, Zhang Y, Chen X, Zhou K, Jin M, Cheng Z, Li X, Jiang L, Wang H, Wan J. Rice LTG1 is involved in adaptive growth and fitness under low ambient temperature. The Plant J. 2014, 78(3): 468–480
8. Tan J#, Tan Z#, Wu F#, Sheng P, Heng Y, Wang X, Ren Y, Wang J, Guo X, Zhang X, Cheng Z, Jiang L, Liu X, Wang H, Wan J. A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice. Mol Plant. 2014, 7(8): 1329-1349
9. Zhou F, Lin Q, Zhu L, Ren Y, Zhou K, Shabek N, Wu F, Mao H, Dong W, Gan L, Ma W, Gao H, Chen J, Yang C, Wang D, Tan J, Zhang X, Guo X, Wang J, Jiang L, Liu X, Chen W, Chu J, Yan C, Ueno K, Ito S, Asami T, Cheng Z, Wang J, Lei C, Zhai H, Wu C, Wang H, Zheng N, Wan J. D14-SCF(D3)-dependent degradation of D53 regulates strigolactone signalling. Nature. 2013 Dec 19; 504 (7480):406-10.
10. Ma X#, Cheng Z#, Wu F#, Jin M, Zhang L, Feng Zhou, Jiulin Wang, Kunneng Zhou, Jian Ma, Qibing Lin, Cailin Lei, Jianmin Wan. BEAK LIKE SPIKELET1 is Required for Lateral Development of Lemma and Palea in Rice. Plant Mol Biol Rep (2013) 31:98–108
11. Wu F#, Xin Q#, Cao Z#, Liu Z†, Du S, Mei C, Zhao C, Wang X, Shang Y, Jiang T, Zhang X, Yan L, Zhao R, Cui Z, Liu R, Sun H, Yang X, Su Z, Zhang D. The magnesium-chelatase H subunit binds abscisic acid and functions in abscisic acid signaling: new evidence in Arabidopsis. Plant Physiol. 2009 Aug;150(4):1940-54.
12. Shen Y#, Wang X#, Wu F#, Du S, Cao Z, Shang Y, Wang X, Peng C, Yu X, Zhu S, Fan R, Xu Y, Zhang D. The Mg-chelatase H subunit is an abscisic acid receptor. Nature. 2006 Oct 19;443(7113):823-6.
(#Equal contributions)
联系方式：
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李寅青
清华大学 研究员
博士生导师
教育经历
2008年 获复旦大学微电子系学士学位
2012年 获麻省理工学院获得电子工程与计算机专业硕士学位
2016年 获麻省理工学院获得电子工程与计算机专业博士学位
2016-2018年 博德研究所、斯坦利精神疾病中心完成博士后研究
2018-至今 清华大学任教
研究方向
复杂疾病的产生和发展往往伴随着一系列发生在分子和细胞层面的关键变化。诊断和治疗的主要挑战之一便是要清晰的理解在疾病的产生和发展过程中，哪个时间点上有哪些分子和细胞发生了关键变化，以及这些变化是如何影响细胞自身和细胞间互相作用的，并通过针对关键分子和细胞的编辑，实现对于疾病的控制。 李寅青博士的研究团队专注于基因组医学技术的三个重要方面的开发。 （1）单细胞表征技术。实现表观遗传组、转录组、信号组单细胞多组学，在时间和空间两个尺度上整体表征分子、细胞、细胞间作用的变化。 （2）基因编辑技术。探索新的编辑系统，基因替换和表观遗传控制，实现细胞从基因到状态的全面调控。 （3）生物信息学。发展与应用统计推断及机器学习算法，分析高通量数据和挖掘原核基因工具。
科学贡献
1、皮层-丘脑回路的单细胞多组学解析 2、单细胞核的转录组技术 3、CRISPR基因编辑工具的改造和特异性表征 4、哺乳动物细胞的合成生物学基因电路模块化构建
所获荣誉
2016年 国家优秀自费留学生，特别优秀奖 2016年 Wenner-Gren Fellowship 2013年 McGovern Institute Fellowship
代表性论文
1. Li Y, Weiss R., A Modular Approach to Building Complex Synthetic Circuits. Methods in Molecular Biology. 2017 pp. 231–248, DOI:10.1007/978-1-4939-7223-4_17.
2. Yan WX, Mirzazadeh R, Garnerone S, Scott D, Schneider MW, Kallas T, Custodio J, Wernersson E, Li Y, Gao L, Federova Y, Zetsche B, Zhang F, Bienko M, Crosetto N., BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks. NATURE COMMUNICATIONS. 2017, 8:15058.
3. Habib N*, Li Y*, Heidenreich M, Swiech L, Avraham-Davidi I, Trombetta JJ, Hession C, Zhang F, Regev A. Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons. SCIENCE. 2016, 353(6302):925-8.
4. Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O. Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA. CELL. 2016, 165(4):949-62.
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李寅青博士个人主页：http://web.mit.edu/yinqingl/www/
“冷泉港亚洲——合成生物学”于11月28日到12月2日，在苏州独墅湖畔召开，参与者来自世界各地。陈国强，戴俊彪和谢震老师参加了此次会议，均作了口头报告；另外参会的6名学生作了口头报告或poster。
谢震老师介绍了利用合成生物学方法在哺乳动物细胞中优化 Cas-9 系统的作用；戴俊彪老师则介绍了酵母染色体合成过程中的一些合成生物学方法的探究和应用；陈国强老师的报告，则是对一种新的合成生物学底盘微生物——盐单胞菌的研究，并结合应用分析了盐单胞菌相较于目前常规底盘微生物的优势。
另外中心的三名同学——凌晨，叶健文和 Dina Elhadi均作了口头报告，三位同学的报告分别着重于理性设计，代谢工程和生产应用三个方面，体现了合成生物学从基础到应用的连续性。
在 poster环节中，中心两名同学获得了优秀墙报奖，戴俊彪老师实验室的罗周卿和陈国强老师实验室的陈祥斌同学分别获得第二和第一名；该奖只设4名，中心学生脱颖而出，展现了我们的风采。
2016年10月11日上午清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所签署合作备忘录（Memorandum of Understanding）签字仪式在清华大学生物新馆举行。曼切斯特大学生物技术研究所主任Nigel S. Scrutton与清华大学合成与系统生物学中心主任陈国强代表双方完成签字仪式。
清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所MOU签字仪式
曼切斯特大学生物技术研究所主任Nigel S. Scrutton在作报告
在签字仪式上，Nigel S. Scrutton主任介绍了曼切斯特大学生物技术研究所工作重点是酶家族称为”ene reduc-Tases”，这将涉及从基本了解酶的机制，物理学，量子生物学和先进的动力学方法，直到应用于生物催化，特别是用于生产单萜调味剂和香料的微生物的工程化。双方就合作领域将是生物技术/合成和系统生物学领域的科学和技术课题达成合作意向。
英国曼切斯特大学生物技术研究所：
英国曼彻斯特生物技术研究所（MIB）以前是曼彻斯特跨学科生物中心。该中心的设计旨在使学术界能够探索跨学科定量生物科学的特定领域，主要是通过多学科研究团队的努力。 MIB的研究遵循三个广泛定义，跨学科和互补的主题：生物机制和催化，分子生物工程，系统生物学。
该研究所的规划于1998年年底开始，最终于2006年10月25日的约翰·加西德大楼正式开幕。该研究所于2012年6月1日更名为曼彻斯特生物技术研究所，保留了首字母缩略词MIB。
清华大学合成与系统生物学中心：
清华大学合成与系统生物学中心骨干包括中科院院士1名、973首席4名、长江杰青8名（人次），优青1名、全国百篇1名。其中，主持了我国10项合成生物学973项目中的2项、以及唯一的生物信息学“973”项目。
研究涉及高通量组学的生物信息学、复杂疾病的网络调控研究、表观基因组学及其遗传机制研究、化学品生物合成及代谢网络研究、基因线路构建及医药应用、基因合成与基因组组装、环境微生物及宏基因组学等研究领域。中心在国际学术界和国内外相关产业界有较好声誉，是国内最重要的合成生物学研究队伍之一。
Nigel S. Scrutton ScD FRSC FRSB,
Director, Manchester Institute of Biotechnology,
Director, Manchester Synthetic Biology Centre, SYNBIOCHEM,
Director, Marie Curie Innovative Doctoral Training Program, MAGIC
EPSRC Established Career Fellow,
Manchester Institute of Biotechnology
University of Manchester
Education background
University of Cambrige
Biography
Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.
Nigel has an established position in the field of enzyme catalysis, biophysics and biomolecular engineering. He is recipient of the Biochemical Society Colworth Medal, the RSC Charmian Medal, the RSC Rita and John Cornforth Award and a Royal Society Wolfson Research Merit Award. He has served on several national steering groups, advisory boards and governing bodies. He heads a group of ca 40 researchers. He has published ca 380 scientific papers, holds several patents, and has edited 3 volumes on enzyme chemistry, quantum biology, biocatalysis, synthetic biology and engineering. He has held contiguous externally funded research fellowships for 29 years. Nigel is Director of the BBSRC/EPSRC Synthetic Biology Research Centre 'SYNBIOCHEM' based in MIB and Director of a Marie Curie IDP 'MAGIC' responsible for the training of 12 early stage researchers at Manchester. Nigel is also a Director of the MIB spin out company C3 Biotechnologies Ltd. He holds visiting professorships at Tsinghua University, China and University of Cardiff, UK.
Nigel’s group is noted internationally for its contributions to enzyme catalysis, especially in the fields of quantum biology (tunneling), protein dynamics and biocatalysis, and more recently synthetic biology in relation to chemicals production. His work is interdisciplinary at the interfaces of chemistry, biology and physics, supported by a genuinely world-leading infrastructure for biophysical chemistry that he has established at Manchester.
Contact Information：
Director Manchester Institute of Biotechnology
Centre for Synthetic Biology 'SYNBIOCHEM'
Manchester Institute of Biotechnology
School of Chemistry
Faculty of Science and Engineering
The University of Manchester
131 Princess Street Manchester
M1 7DN
UK
Tel: +44 (0) 161 306 5152
Fax: +44 (0) 161 306 5199
Mobile: +44 7917 592392
2016年10月11日上午清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所签署合作备忘录（Memorandum of Understanding）签字仪式在清华大学生物新馆举行。曼切斯特大学生物技术研究所主任Nigel S. Scrutton与清华大学合成与系统生物学中心主任陈国强代表双方完成签字仪式。
清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所MOU签字仪式
曼切斯特大学生物技术研究所主任Nigel S. Scrutton在作报告
在签字仪式上，Nigel S. Scrutton主任介绍了曼切斯特大学生物技术研究所工作重点是酶家族称为”ene reduc-Tases”，这将涉及从基本了解酶的机制，物理学，量子生物学和先进的动力学方法，直到应用于生物催化，特别是用于生产单萜调味剂和香料的微生物的工程化。双方就合作领域将是生物技术/合成和系统生物学领域的科学和技术课题达成合作意向。
英国曼切斯特大学生物技术研究所：
英国曼彻斯特生物技术研究所（MIB）以前是曼彻斯特跨学科生物中心。该中心的设计旨在使学术界能够探索跨学科定量生物科学的特定领域，主要是通过多学科研究团队的努力。 MIB的研究遵循三个广泛定义，跨学科和互补的主题：生物机制和催化，分子生物工程，系统生物学。
该研究所的规划于1998年年底开始，最终于2006年10月25日的约翰·加西德大楼正式开幕。该研究所于2012年6月1日更名为曼彻斯特生物技术研究所，保留了首字母缩略词MIB。
清华大学合成与系统生物学中心：
清华大学合成与系统生物学中心骨干包括中科院院士1名、千人计划1名、973首席4名、长江杰青8名（人次），青年千人计划8名、优青1名、全国百篇1名。其中，主持了我国10项合成生物学973项目中的2项、以及唯一的生物信息学“973”项目。
研究涉及高通量组学的生物信息学、复杂疾病的网络调控研究、表观基因组学及其遗传机制研究、化学品生物合成及代谢网络研究、基因线路构建及医药应用、基因合成与基因组组装、环境微生物及宏基因组学等研究领域。中心在国际学术界和国内外相关产业界有较好声誉，是国内最重要的合成生物学研究队伍之一。