“冷泉港亚洲——合成生物学”于11月28日到12月2日，在苏州独墅湖畔召开，参与者来自世界各地。陈国强，戴俊彪和谢震老师参加了此次会议，均作了口头报告；另外参会的6名学生作了口头报告或poster。

                               谢震老师介绍了利用合成生物学方法在哺乳动物细胞中优化 Cas-9 系统的作用；戴俊彪老师则介绍了酵母染色体合成过程中的一些合成生物学方法的探究和应用；陈国强老师的报告，则是对一种新的合成生物学底盘微生物——盐单胞菌的研究，并结合应用分析了盐单胞菌相较于目前常规底盘微生物的优势。 

               另外中心的三名同学——凌晨，叶健文和 Dina Elhadi均作了口头报告，三位同学的报告分别着重于理性设计，代谢工程和生产应用三个方面，体现了合成生物学从基础到应用的连续性。 

                在 poster环节中，中心两名同学获得了优秀墙报奖，戴俊彪老师实验室的罗周卿和陈国强老师实验室的陈祥斌同学分别获得第二和第一名；该奖只设4名，中心学生脱颖而出，展现了我们的风采。

        2016年10月11日上午清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所签署合作备忘录（Memorandum of Understanding）签字仪式在清华大学生物新馆举行。曼切斯特大学生物技术研究所主任Nigel S. Scrutton与清华大学合成与系统生物学中心主任陈国强代表双方完成签字仪式。

清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所MOU签字仪式

曼切斯特大学生物技术研究所主任Nigel S. Scrutton在作报告

      在签字仪式上，Nigel S. Scrutton主任介绍了曼切斯特大学生物技术研究所工作重点是酶家族称为”ene reduc-Tases”，这将涉及从基本了解酶的机制，物理学，量子生物学和先进的动力学方法，直到应用于生物催化，特别是用于生产单萜调味剂和香料的微生物的工程化。双方就合作领域将是生物技术/合成和系统生物学领域的科学和技术课题达成合作意向。

英国曼切斯特大学生物技术研究所：

      英国曼彻斯特生物技术研究所（MIB）以前是曼彻斯特跨学科生物中心。该中心的设计旨在使学术界能够探索跨学科定量生物科学的特定领域，主要是通过多学科研究团队的努力。 MIB的研究遵循三个广泛定义，跨学科和互补的主题：生物机制和催化，分子生物工程，系统生物学。

      该研究所的规划于1998年年底开始，最终于2006年10月25日的约翰·加西德大楼正式开幕。该研究所于2012年6月1日更名为曼彻斯特生物技术研究所，保留了首字母缩略词MIB。

 清华大学合成与系统生物学中心：

      清华大学合成与系统生物学中心骨干包括中科院院士1名、973首席4名、长江杰青8名（人次），优青1名、全国百篇1名。其中，主持了我国10项合成生物学973项目中的2项、以及唯一的生物信息学“973”项目。

       研究涉及高通量组学的生物信息学、复杂疾病的网络调控研究、表观基因组学及其遗传机制研究、化学品生物合成及代谢网络研究、基因线路构建及医药应用、基因合成与基因组组装、环境微生物及宏基因组学等研究领域。中心在国际学术界和国内外相关产业界有较好声誉，是国内最重要的合成生物学研究队伍之一。

Nigel S. Scrutton ScD FRSC FRSB,

Director, Manchester Institute of Biotechnology,

Director, Manchester Synthetic Biology Centre, SYNBIOCHEM,

Director, Marie Curie Innovative Doctoral Training Program, MAGIC

EPSRC Established Career Fellow,

Manchester Institute of Biotechnology

University of Manchester

Education background

University of Cambrige

Biography

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Nigel has an established position in the field of enzyme catalysis, biophysics and biomolecular engineering. He is recipient of the Biochemical Society Colworth Medal, the RSC Charmian Medal, the RSC Rita and John Cornforth Award and a Royal Society Wolfson Research Merit Award. He has served on several national steering groups, advisory boards and governing bodies. He heads a group of ca 40 researchers. He has published ca 380 scientific papers, holds several patents, and has edited 3 volumes on enzyme chemistry, quantum biology, biocatalysis, synthetic biology and engineering. He has held contiguous externally funded research fellowships for 29 years. Nigel is Director of the BBSRC/EPSRC Synthetic Biology Research Centre 'SYNBIOCHEM' based in MIB and Director of a Marie Curie IDP 'MAGIC' responsible for the training of 12 early stage researchers at Manchester. Nigel is also a Director of the MIB spin out company C3 Biotechnologies Ltd. He holds visiting professorships at Tsinghua University, China and University of Cardiff, UK.

Nigel’s group is noted internationally for its contributions to enzyme catalysis, especially in the fields of quantum biology (tunneling), protein dynamics and biocatalysis, and more recently synthetic biology in relation to chemicals production. His work is interdisciplinary at the interfaces of chemistry, biology and physics, supported by a genuinely world-leading infrastructure for biophysical chemistry that he has established at Manchester.

Contact　Information：

Director Manchester Institute of Biotechnology

Centre for Synthetic Biology 'SYNBIOCHEM'

Manchester Institute of Biotechnology

School of Chemistry

Faculty of Science and Engineering

The University of Manchester

131 Princess Street Manchester

M1 7DN

UK

Tel: +44 (0) 161 306 5152

Fax: +44 (0) 161 306 5199

Mobile: +44 7917 592392 

2016年10月11日上午清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所签署合作备忘录（Memorandum of Understanding）签字仪式在清华大学生物新馆举行。曼切斯特大学生物技术研究所主任Nigel S. Scrutton与清华大学合成与系统生物学中心主任陈国强代表双方完成签字仪式。

清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所MOU签字仪式

曼切斯特大学生物技术研究所主任Nigel S. Scrutton在作报告

在签字仪式上，Nigel S. Scrutton主任介绍了曼切斯特大学生物技术研究所工作重点是酶家族称为”ene reduc-Tases”，这将涉及从基本了解酶的机制，物理学，量子生物学和先进的动力学方法，直到应用于生物催化，特别是用于生产单萜调味剂和香料的微生物的工程化。双方就合作领域将是生物技术/合成和系统生物学领域的科学和技术课题达成合作意向。

英国曼切斯特大学生物技术研究所：

英国曼彻斯特生物技术研究所（MIB）以前是曼彻斯特跨学科生物中心。该中心的设计旨在使学术界能够探索跨学科定量生物科学的特定领域，主要是通过多学科研究团队的努力。 MIB的研究遵循三个广泛定义，跨学科和互补的主题：生物机制和催化，分子生物工程，系统生物学。

该研究所的规划于1998年年底开始，最终于2006年10月25日的约翰·加西德大楼正式开幕。该研究所于2012年6月1日更名为曼彻斯特生物技术研究所，保留了首字母缩略词MIB。

 清华大学合成与系统生物学中心：

清华大学合成与系统生物学中心骨干包括中科院院士1名、千人计划1名、973首席4名、长江杰青8名（人次），青年千人计划8名、优青1名、全国百篇1名。其中，主持了我国10项合成生物学973项目中的2项、以及唯一的生物信息学“973”项目。

研究涉及高通量组学的生物信息学、复杂疾病的网络调控研究、表观基因组学及其遗传机制研究、化学品生物合成及代谢网络研究、基因线路构建及医药应用、基因合成与基因组组装、环境微生物及宏基因组学等研究领域。中心在国际学术界和国内外相关产业界有较好声誉，是国内最重要的合成生物学研究队伍之一。

Time: 9:30-11:00,  Oct 11st (Tuesday)

Venue: Room 143, New Biology Building, THU

Host: Dr. CHEN Guo-Qiang

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Abstract

 I have been fascinated by the complexity and catalytic capabilities of enzymes throughout my career. My group has pursued research on the mechanisms and structures of biocatalysts - and more recently on light-responsive proteins - and integrated these studies into ambitious synthetic biology and metabolic engineering programmes (e.g. for chemicals production). My group has undertaken ambitious, wide-ranging interdisciplinary programmes in experimental enzyme biophysics and integrated these with structural and chemical biology, computational simulation and theory. Highlights have included demonstration of the unexpected importance of nuclear tunneling mechanisms in biological catalysis, discovery of new biological cofactors (e.g. prenylated flavins), structures of enzymes in complex with lead drug compounds (e.g. for Huntington's chorea/Alzheimer's disease) and mechanistic understanding of new roles for vitamin B12 and other photoreceptors in light-activated transcriptional regulation. In the fields of metabolic engineering/synthetic biology/directed evolution we have engineered organisms to biosynthesize propane gas and a wide array of monoterpenoid products. These programmes have their foundations in basic discovery science and in selected cases extend to commercial exploitation through spin out activity.

In this lecture I will highlight selected aspects of our work focused on the enzyme family termed ‘ene reductases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances. The lecture will also highlight infrastructure and capabilities available in the Manchester Synthetic Biology Centre (SYNBIOCHEM) that I established recently and for which I am Director.

Time: 9:30-11:00,  Oct 11st (Tuesday)

Venue: Room 143, New Biology Building, THU

Host: Dr. CHEN Guo-Qiang

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Abstract

 I have been fascinated by the complexity and catalytic capabilities of enzymes throughout my career. My group has pursued research on the mechanisms and structures of biocatalysts - and more recently on light-responsive proteins - and integrated these studies into ambitious synthetic biology and metabolic engineering programmes (e.g. for chemicals production). My group has undertaken ambitious, wide-ranging interdisciplinary programmes in experimental enzyme biophysics and integrated these with structural and chemical biology, computational simulation and theory. Highlights have included demonstration of the unexpected importance of nuclear tunneling mechanisms in biological catalysis, discovery of new biological cofactors (e.g. prenylated flavins), structures of enzymes in complex with lead drug compounds (e.g. for Huntington's chorea/Alzheimer's disease) and mechanistic understanding of new roles for vitamin B12 and other photoreceptors in light-activated transcriptional regulation. In the fields of metabolic engineering/synthetic biology/directed evolution we have engineered organisms to biosynthesize propane gas and a wide array of monoterpenoid products. These programmes have their foundations in basic discovery science and in selected cases extend to commercial exploitation through spin out activity.

In this lecture I will highlight selected aspects of our work focused on the enzyme family termed ‘ene reductases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances. The lecture will also highlight infrastructure and capabilities available in the Manchester Synthetic Biology Centre (SYNBIOCHEM) that I established recently and for which I am Director.

时间：6.14-6.17

地点：北京，上海，深圳

注册参会链接：http://synbiobeta.com/conferences/synbiobeta-china-2016/

 该会议的重点是通过整合来自企业家、学术界、产业界、政策制定者、和投资者等之间的多方关系，来促进合成生物学在中国生态系统和产业化方面的发展。通过这次活动，您不仅可以与相关的行业领袖、学者、投资人、以及企业家建立一个交流切磋、合作共赢的关系网络，还可以了解到全球最新合成生物学产业的发展动向，新技术的开发及其应用等信息。

大会报告人来自不同国家（包括美国，英国和中国）的多个行业，包括生物医药和农业，重点讨论自动化工具（如CAD）的应用以及新的DNA合成方法等。

本次会议将会让以下几种合成生物学爱好者们受益匪浅：

•技术从业者

•工业和新兴创业公司

•政府机构及投资者

•高科技开发人员

•学术及科研人员

•学生和生物爱好者

通过参加这次活动，您会发现谁是率先在中国进行合成生物学产业化研究并将其商业化的领军人物，而且，您还会深入全面的了解到合成生物学的全球发展趋势，并有机会找到合作或投资的绝佳契机。

2016年5月16日，生命学院朱听课题组与化学系刘磊课题组合作在Nature Chemistry杂志在线发表了题为 “A synthetic molecular system capable of mirror-image genetic replication and transcription”《合成镜像生物分子系统实现遗传信息复制与转录》的论文。该论文首次通过化学合成镜像聚合酶实现了中心法则中DNA的复制与转录这两个关键步骤。Nature在线新闻同步报道并评述了该研究。

原文链接：http://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2517.html

Nature新闻链接：http://www.nature.com/news/mirror-image-enzyme-copies-looking-glass-dna-1.19918

地球上已知所有生物都具有手性均一的特征，即构成生命的蛋白质几乎均由L型氨基酸组成，而DNA和RNA均由D型核糖组成；迄今为止还没有证据表明反手性生命系统在进化中曾经出现过。生命学院朱听课题组与化学系刘磊课题组合作，用化学合成方法构建了基于镜像ASFV pol X聚合酶的遗传信息复制与转录系统。该研究结果表明镜像DNA的复制与转录同样遵循碱基互补配对原则，并具有良好的手性特异性。由该镜像分子系统聚合得到的镜像DNA核酶实现了与天然DNA核酶相同的自剪切功能。该研究有望被用来聚合实用反手性核酸大分子，同时也向实现构建镜像生命系统迈出了重要的一步。

朱听课题组致力于合成生物学、基因组学研究。本文第一作者为生命学院2013级硕士研究生王子谋和化学系博士后徐维亮，通讯作者为生命学院朱听研究员和化学系刘磊教授。本课题得到国家自然科学基金委、科技部、清华大学自主科研计划、清华-北大生命科学联合中心、感染性疾病诊治协同创新中心的经费支持。

May 17th, 2016

Room 101，Yingshi Building, Department of Chemical Engineering

Tsinghua University, Beijing, China

Biological technology is becoming essential platform for healthcare,green industry, low carbon economy and sustainable society. Aiming at promotion of the mutual exchange and cooperation for scientific research and technology development, 2016 Tsinghua-EMBL Forum on Advanced Biological Technology (THE-FAB’2016) will be held in Tsinghua University, Beijing, China, from May 16th to 19th, 2016. THEFAB’ 2016 is jointly organized by Tsinghua University, China, and European Molecular Biology Laboratory (EMBL), Germany. Scope of THE-FAB’2016 will cover the academic research activities and technology transfer in pioneering biological technologies from biomolecules to cellular systems. This Forum will also provide an opportunity for mutual exchange of technology transformation based on basic research for both sides.

Organizers

Tsinghua University

European Molecular Biology Laboratory (EMBL)

Key Lab of Industrial Biocatalysis, Ministry of Education

Sponsor

XIN Center, Tsinghua University

Forum Chairpersons

Prof. Xin-Hui Xing Tsinghua University

Dr. Silke Schumacher EMBL

Important dates for the symposium

1) First circular: March 8th, 2016,

2) April 30th, 2016, abstract submission deadline

3) April 15th, 2016, Invitation letter (including materials for visa application if required)

4) May 1st, 2016, second circular, and the symposium program

AGENDA ON MAY 17TH, 2016

Place: Room 101, Yingshi Building, Tsinghua University

Contact information

Dr. Nan Su

Department of Chemical Engineering,

Tsinghua University, Beijing 100084, PRC.

Tel: +86-10-6277-3004 -806

Cell phone number: +86-18610372509

Fax: +86-10-6277-0304

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Dr. Shanshan Du

Department of Chemical Engineering,

Tsinghua University, Beijing 100084, PRC.

Tel: +86-10-6277-3004 -806

Cell phone number: +86-13011090989

Fax: +86-10-6277-0304

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Curriculum Vitae of Speakers:

ZhiJie Chang (Tsinghua Univ)

George Guo-Qiang Chen (Tsinghua Univ)

XinHui Xing((Tsinghua Univ)

Ye Xiang(Tsinghua Univ)  

YanMei Li(Tsinghua Univ)

Qi Jiang(Tsinghua Univ)

Jun Ma (Tsinghua Univ)

Xiao Jun Lu(Tsinghua Univ)

Matthias Wilmanns(EMBL)

Rob Meijers(EMBL)

Henning Hermjakob（EMBL-EBI ）

Jürgen Bauer (EMBLEM）

Charles E. Cook (EMBL)

Plamena Markova, LL.M(EMBL))

Dr. Silke Schumacher(EMBL)

清华附中生物竞赛班高一的十几位同学表示对合成生物学有兴趣，希望到中心的PI实验室学习。同学们选择了感兴趣的实验室。

中心相关的PI实验室在尽量培养同学们的兴趣的基础上给予更多的知识和帮助。同学们在新的环境下经过老师的辅导都有很大的进步。

老师们希望通过大家努力关照好这几位同学，他们都将是我们生命科学的的接班人，继承者。