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    2014年8月6日清华大学生命科学学院邓海腾课题组在《Molecular & Cellular Proteomics》上在线发表了题为"Down-regulation of Rab 5C-dependent Endocytosis and Glycolysis in Cisplatin-resistant Ovarian Cancer Cell Lines"的研究论文。该论文通过定量蛋白质组学分析，发现了多个与卵巢癌细胞顺铂耐药性相关的因素，包括Rab 5C调控的内吞作用，糖酵解相关蛋白和波形蛋白的下调，以及抗氧化蛋白的上调，为系统理解卵巢癌细胞的耐药机制提供了实验依据。

　　耐药性一直是卵巢癌临床治疗上的屏障，严重影响卵巢癌患者的生存率。本项工作通过对非耐药的卵巢癌细胞进行顺铂递增浓度的处理和筛选，建立起了顺铂耐药的细胞系；然后利用TMT标记的定量蛋白质组学方法，鉴定出卵巢癌细胞A2780及其顺铂耐药细胞A2780-DR中有差异表达的蛋白340个；并利用生物信息学的方法对这些差异蛋白进行功能的分析及分类。其中，作者发现Rab 5C在耐药细胞中的表达是下调的。Rab 5C调控细胞的内吞过程。为了证明Rab 5C的下调影响顺铂在细胞中的积累从而导致耐药。作者对A2780细胞中的Rab5C进行了shRNA介导的基因沉默， 结果发现基因沉默可增加细胞对顺铂的耐药性；相反，过表达Rab 5C可使细胞对顺铂更加敏感。这些结果显示卵巢癌细胞的耐药性由多个因素决定，包括Rab 5C和Rab 11B调控的细胞內吞作用。

　　本论文的通讯作者为清华大学生命科学学院的邓海腾教授，该课题组的二年级博士生霍祎是该论文的并列第一作者，生物医学测试中心蛋白质化学平台的技术人员参与了该项工 作的样品分析。该研究受国家自然科学基金（31270871）和清华-北大生命科学联合中心经费的支持。

清华大学生物医学工程系

Geometric tools for biomedical image analysis - 清华大学生物医学工程系

    以上是经三方招生委员会面试后形成的拟录取名单，之后将进行资格复审，以下情况资格复审不能通过：

   1）录取单位调剂后没有进行有效报名的人员；

    2）自身情况介绍、成绩排名、档案材料以及报名时递交的其他材料中有弄虚作假者；

    3）其他特殊情况。

      资格复审未通过者将被取消录取资格。

     生命学院、医学院基础医学系、清华大学-北京大学生命科学联合中心

                                   2015年10月19日

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生命学院刘万里实验室招聘博士后

实验室研究方向：

分子免疫学、细胞生物学、疫苗学。应用高速高分辨率的活细胞单分子荧光成像技术，并结合传统的免疫学、生物化学和生物物理研究手段，致力于淋巴细胞功能研究。正在开展的工作包括：（1）淋巴细胞活化的分子机制及调控机制的研究；（2）淋巴细胞异常活化导致的自身免疫疾病及淋巴癌和白血病的研究；（3）免疫记忆的分子机制；（4）淋巴细胞感受机械力的生物学；（5）病原微生物作用于淋巴细胞活化途径的免疫逃逸新机制；（6）构建基于上述知识的新型疫苗和新型抗体药物。

招聘岗位：博士后

应聘条件：

1.        具有生物学、基础医学、光电工程等相关专业博士学位；

2.        工作严谨条理、诚信、有责任心；具备良好的独立科研能力和英文写作阅读能力。

岗位待遇：

按照清华大学博士后管理规定执行，解决博士后期间的子女入托、入学问题；在清华大学博士后的标准薪酬基础上，对于具有优异学术发展潜力的博士后，我们将提供具有国际竞争力的特别资助以及其他相关待遇。

申请方式：

申请人请将一份详细的个人简历（包括推荐人联系方式）发送至该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

陈国强

清华大学 生命科学学院

教授，博士生导师

教育部长江学者特聘教授

教育经历

1985年      获华南理工大学学士学位

1989年      获奥地利格拉茨(Graz)工业大学博士学位

1990-1994年 英国诺丁汉(Notthingham)大学和加拿大阿尔伯达(Alberta)大学做博士后研究

1994年      被聘为清华大学副教授

1997年      聘为教授

研究方向

长期从事“微生物和生物材料”的研究。在国际学术期刊上共发表微生物技术和生物材料相关论文200多篇， Web of Sciences纪录论文被引用八千多次次(H指数为47)。获得授权专利30项，40个公开专利。开发的技术已经在数家公司用于大规模生产微生物塑料聚羟基脂肪酸酯PHA。

担任职务

清华大学合成与系统生物学中心主任

973“合成生物学”项目的首席科学家。

另担任下面国际国内学术期刊《Journal of Biotechnology》 、《Microbial Cell Factories》、《Biotechnology Journal》、《Plos One》和《中国生物工程学报》副主编。另担任《Current Opinions in Biotechnology》、《Applied Microbiology and Biotechnology》、《Biomaterials》、《Biomacromolecules》、《Artificial Cells, Blood Substitutes and Biotechnology》、《ACS Synthetic Biology》和《Asia Pacific Biotech News》编委 。

所获荣誉

教育部长江学者特聘教授、第八届中国青年科技奖、自然科学基金委国家杰出青年、纽伦堡国际发明奖、国家发明二等奖(排名第一)、谈家祯生命科学创新奖、茅以升科技奖、首届闵恩泽能源化工杰出贡献奖、候德傍化工创新奖和教育部高校青年教师奖等。曾连续6年获得清华大学学生“良师益友”的光荣称号，进入清华大学“良师益友”名人堂。连续7年获得清华大学高论文他引的“梅贻琦奖”。

代表论文

1. Dong CL, Webb WR, Peng Q, Tang JZ, Forsyth NR, El Haj AJ and Chen GQ. A 3D collagen hydrogels stem cell tissue engineered formulation basing on growth factor phospholipid complex loaded PHBHHx nanoparticles. Journal of Biomedical Materials Research Part A 103 (2015) 282-288
2. Yin Jin, Chen GQ. Halomonas spp, a Rising Star for Industrial Biotechnology. Biotechnology Advance 10.1016/j.biotechadv.2014.10.008 (2015)
3. Guo YY, Shi ZY, Fu XZ, Chen JC, Wu Q and Chen GQ. Enhance General Circular DNA Construction Efficiency by Circumventing Long-Standing Contradictions among Ligation/Assembly and Transformation Steps. Microbial Cell Factories 2015, 14:18
4. Yin J, Wang H, Gao X, Fu XZ, Wu Q and Chen GQ. Effects of chromosomal gene copy number and locations on polyhydroxyalkanoates synthesis by Escherichia coli and Halomonas Appl Microbiol Biotechnol 99 (2015) 5523–5534
5. Lv L, Ren YL, Chen JC, Wu Q and Chen GQ. Application of CRISPRi for Prokaryotic Metabolic Engineering Involving Multiple Genes, A Case Study: Controllable P(3HB-co-4HB) Biosynthesis. Metabolic Engineering 29 (2015) 160–168
6. Meng DC, Wang Ying, Shen Rui, Chen JC, Wu Q and Chen GQ. Production of Poly(3-Hydroxypropionate) and P(3_Hydroxybutyrate-co-3-Hydroxypropionate) from Glucose by Engineered coli. Metabolic Engineering 29 (2015) 189–195
7. Jiang XR, Wang H, Shen R, Chen GQ. Engineering the Bacterial Shapes for Enhanced Inclusion Bodies Accumulation. Metabolic Engineering 29 (2015) 227-237
8. Guo YK, Dong JK, Zhou T, Li TY, Zhang WM, Wang LH, Auxillos J, Shen Y, Luo YS, Zheng YJ, Lin JW, Chen GQ, Wu QY, Cai YZ, Dai J The design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae. Nucleic Acid Research (2015) e88.
9. Chen GQ, Hajnal I, Ma YM, Wu H, Ye JW. Engineering the bacterial synthesis mechanism for diversifying polyhydroxyalkanoates. Trends in Biotechnology 33 (2015) 565-574
10. Chen GQ, Hajnal I. The “PHAome”. Trends in Biotechnology 33 (2015) 559-564

联系方式

清华大学生命科学学院，生物新馆101

北京100084，中国

电话：+86-010-62783844

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