李雪明
清华大学 研究员
博士生导师
教育经历
1998-2002年 北京科技大学 材料物理系 学士
2002-2005年 北京科技大学 材料物理与化学系 硕士
2005-2009年 中科院物理研究所 凝聚态物理 博士
2009-2013年 加州大学旧金山分校 博士后
2014年至今 清华大学生命科学学院，清华-北大生命科学联合中心，北京结构生物学高精尖中心 研究员
研究方向
主要从事冷冻电子显微学理论和方法研究，着重于开发和利用最新的电子显微学技术，以提高冷冻电子显微学三维重构的分辨率到原子水平；同时致力于将电子显微学应用到结构生物学研究中去，以解决与结构相关的重要生物学问题。在生物方面，从事细菌外膜分泌系统的结构与功能研究。
科学贡献
所获荣誉
2015. Youth One-Thousand Program by State Council of China青年千人)
2015. QiuShi Award for Excellent Young Scientis（求是杰出青年学者）
2016. the National Science Fund for Excellent Young Scholars（优青）
代表性论文
1. Li Wang#, Heng Zhou#, Mingmin Zhang#, Wenhao Liu#, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li*, Bailong Xiao*, Structure and mechanogating of the mammalian tactile channel PIEZO2, Nature, 2019, 573, 225-229
2. Heng zhou#, Feng Luo#, Zhipu Luo#, Dan Li, Cong Liu*, Xueming Li*, Programming conventional electron microscopes for solving ultrahigh-resolution structures of small and macro-molecules, Analytical Chemistry, 2019, 91, 10996-11003
3. Meijing Li#, Xian Xia#, Yuanyuan Tian#, Qi Jia#, Xiaoyu Liu#, Ying Lu, Ming Li*, Xueming Li*, and Zhucheng Chen*, Mechanism of DNA translocation underlying chromatin remodeling by Snf2, Nature, 2019, 567, 409-413
4. Heng Zhou#, Zhipu Luo#, Xueming Li*, Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction, Journal of Structural Biology, 2019, 205, 59-64
5. Meng Yin#, Zhaofeng Yan#, Xueming Li*, Architecture of type VI secretion system membrane core complex, Cell Research, 2019, 29, 251-253
6. Mingxu Hu#, Hongkun Yu#, Kai Gu#, Zhao Wang, Huabin Ruan, Kunpeng Wang, Siyuan Ren, Bing Li, Lin Gan, Shizhen Xu, Guangwen Yang*, Yuan Shen*, Xueming Li*, A particle-filter framework for robust cryoEM 3D reconstruction, Nature Methods, 2018, 15, 1083-1089
7. Yaowang Li#, Chunyu Zhao#, Feng Luo#, Zhenying Liu, Xinrui Gui, Zhipu Luo, Xiang Zhang, Dan Li*, Cong Liu* and Xueming Li*, Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy, Cell Research, 2018, 28, 897-903.
8. Meng Yin#, Zhaofeng Yan#, Xueming Li, Structural insight into the assembly of the Type II Secretion System Pilotin-Secretin Complex from enterotoxigenic Escherichia coli, Nature Microbiology, 2018, 3,581-587.
9. Feng Luo#, Xinrui Gui#, Heng Zhou#, Jinge Gu, Yichen Li, Xiangyu Liu, Minglei Zhao, Dan Li*, Xueming Li*, Cong Liu*, Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation, Nature Structural & Molecular Biology, 2018, 25, 341–346
10. Qiancheng Zhao#, Heng Zhou#, Shaopeng Chi#, Yanfeng Wang#, Jianhua Wang, Jie Geng, Kun Wu, Wenhao Liu, Tingxin Zhang, Meng-Qiu Dong, Jiawei Wang, Xueming Li*, Bailong Xiao*. Structure and mechanogating mechanism of the Piezo1 channel. Nature, 2018, 554, 487-492.
11. Xiaoyuan Zhou#, Minghui Li#, Deyuan Su, Qi Jia, Huan Li, Xueming Li*& Jian Yang*,Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states, Nature Structural & Molecular Biology, 2017, 24, 1146-1154
12. Zhaofeng Yan#, Meng Yin#, Dandan Xu, Yongqun Zhu*, Xueming Li*, Structural Insights into Secretin Translocation Channel in Type II Secretion System, Nature Structure & Molecular Biology, 2017, 24, 177-183.
13. Minghui Li#, Xiaoyuan Zhou#, Shu Wang, Ye Gong, Deyuan Su, Huan Li, Xueming Li*, and Jian Yang*, Cryo-EM structure of a eukaryotic cyclic nucleotide-gated channel, Nature, 2017, 542, 60-65.
14. Xiaoyu Liu#, Meijing Li#, Xian Xia#, Xueming Li*, and Zhucheng Chen*,Mechanism of chromatin remodeling revealed by the Snf2-nucleosome structure, Nature, 2017, 544, 440-445.
15. Feng Wang#, Huichao Gong#, Gaochao Liu,# Meijing Li , Chuangye Yan, Tian Xia*, Xueming Li*, Jianyang Zeng*, DeepPicker: a Deep Learning Approach for Fully Automated Particle Picking in Cryo-EM, Journal of Structural Biology, 2016(195), 325-336
16. Xueming Li, Shawn Zheng, David A. Agard, Yifan Cheng, Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage, Journal of Structural Biology, 192, 174-178, 2015
17. Soyeon Park#, Xueming Li#, Homin Kim#, Chingakham Ranjit Singh, Geng Tian, Martin A. Hoyt, Scott Lovell, Kevin P. Battaile, Michal Zolkiewski, Philip Coffino, Jeroen Roelofs*, Yifan Cheng*, and Daniel Finley*, Reconfiguration of the proteasome during chaperone-mediated assembly, Nature, 497, 512-516, 2013. (*co-first author)
18. Xueming Li, Paul Mooney, Shawn Zheng, Chris Booth, Michael B. Braunfeld, Sander Gubbens, David A. Agard* and Yifan Cheng*, Electron counting and beam-induced motion correction enable near atomic resolution single particle cryoEM, Nature Methods, 10, 584-590, 2013.
¶ Featured in Nature Methods News and Views: Robert M. Glaeser (2013) Stroboscopic imaging of macromolecular complexes. Nature Methods 10, 475-476.
¶ Featured in Nature Methods: Method of the Year 2013.
¶ Featured in Science: Martin T.J. Smith and John L. Rubinstein (2014), Beyond blob-ology: Advanced cryo-electron microscopy yields high-resolution structures of proteins, Science 345, 617
19. Xueming Li, Shawn Zheng, Kiyoshi Egami,David A. Agard*, Yifan Cheng*, Influence of electron dose rate on electron counting images recorded with the K2 camera, J Struct. Biol., 184, 251-260, 2013.
20. Xueming Li, Nikolaus Grigorieff, Yifan. Cheng*, GPU-enabled FREALIGN: accelerating single particle 3D reconstruction and refinement in Fourier space on graphics processors, J Struct Biol., 172, 407-12, 2010
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