李春

清华大学  化工系生物化工研究所

教  授      博士生导师

国家杰出青年科学基金获得者

教育经历

2001.08 –2003.10  清华大学      生物化工   博士后

1998.02 –2001.08  天津大学      生物化工   博士

1997.08 –1998.02  天津科技大学  发酵工程   进修

1997.07 –1997.08  中国农业大学  食品生物技术培训

1992.08 –1995.06  石河子大学    微生物学   硕士

1988.09 –1992.07  石河子大学    植物保护   学士

工作简历

2017.09 –2020.04  北京理工大学特聘教授、化学与化工学院副院长，化学工程与技术学科责任教授

2011.02 –2012.01  美国伊利诺伊大学香槟分校（UIUC）化工与生物分子工程系从事合成生物学研究

2005.05 –2017.09  北京理工大学百人计划教授、生物工程系主任，学科责任教授

2003.10 –2006.05  石河子大学教授、校长助理，建立化学化工学院并担任首届院长

2001.08 –2003.10  清华大学化工系从事生物化工领域的博士后研究，石河子大学副教授

1995.07 –1997.06  石河子大学食品工程学院实验中心主任，讲师

研究方向

长期开展1）天然产物的微生物合成与生物转化；2）工业微生物的抗逆重编程与工程应用；3）农业微生物菌剂工程的研究工作。在ACS Energy Lett、 ACS Catal、N C、AIChE J、Chem Eng Sci、Metabolic Eng、ACS Synth Biol、JBC、AEM、J PhyChem Lett、中国科学和化工学报等期刊发表论文220余篇，Web of Science引用超过3000次。获授权国家发明专利31项，近十年完成了4项技术的产业化应用与示范。

获奖荣誉

2004年入选教育部“新世纪优秀人才计划”，2005年获“霍英东青年基金奖”，2006年享受国务院政府特殊津贴，2014年获得国家杰出青年科学基金，2017年获得“侯德榜化工科技创新奖”，2017年遴选为全国“生物工程学”首席科学传播专家。获省部级科技成果奖励4项。组织并指导大学生的合成生物学作品连续7年获得美国MIT主办的“国际遗传工程机器竞赛” （iGEM）金奖（2012-2019）。

代表性论文

1. Sun Wentao, Xue Haijie, Liu Hu, Lv Bo, Yu Yang*, Wang Ying*, Huang Meilan, Li Chun*, Controlling chemo- and regioselectivity of a plant P450 in yeast cell toward rare licorice triterpenoid biosynthesis. ACS Catalysis 2020, 4253-4260.
2. Liu Hu,Cao Mingming,Wang Ying,Lv Bo andLi Chun*. Bioengineering oligomerization and monomerization of enzymes: learning from natural evolution to matching the demands for industrial applications. Critical Reviews in Biotechnology, 2020, 40(2):231-246 
3. Xu Ke, Qin Lei, Bai Wenxin, Wang Xiaoyan, Li Fan, Ren Shichao, Gao Xiaopeng, Chen Bo, Tong Yi, Li Jun, Li Bing-Zhi, Yuan Ying-Jin, and Li Chun*. Multilevel Defense System (MDS) Relieves Multiple Stresses for Economically Boosting Ethanol Production of Industrial Saccharomyces cerevisiaACS Energy Lett. 2020, 5, 572−582
4. Ming Zhu, Caixia Wang, Wentao Sun, Anqi Zhou, Ying Wang, Genlin Zhang, Xiaohong Zhou, Yixin Huo, Li Chun*. Boosting 11-oxo-β-amyrin and glycyrrhetinic acid synthesis in Saccharomyces cerevisiae via pairing novel oxidation and reduction system. Metabolic Engineering, 2018, 45, 43-50.
5. Ke Xu，Bo Lv，Yi-Xin-Huo，Li Chun*. Toward the lowest energy consumption and emission in biofuel production: combination of ideal reactors and robust hosts. Current Opinion in Biotechnology, 2018, 50: 19-24.
6. Lv Bo, Sun Hanli, Huang Shen, Feng Xudong, Jiang Tao, Li Chun*.  Structure-guided engineering of the substrate specificity of a fungal β-glucuronidase toward triterpenoid saponins. Journal of Biological Chemistry, 2018, 93(2):433-443.
7. Yu Yuan, Chang Pengcheng, Yu Huan, Ren Huiyong, Hong Danning, Li Zeyan, Wang Ying, Song Hao, Huo Yixin and Li Chun*. Productive Amyrin Synthases for Efficient α-amyrin Synthesis in Engineered Saccharomyces cerevisiae. ACS Synthetic Biology, 2018, 7(10), 2391-2402.
8. Xudong Feng, Xiaoyan Wang, Beijia Han, Changling Zou, Yuhui Hou, Lina Zhao and Chun Li*.  Design of Glyco-Linkers at Multiple Structural Levels to Modulate Protein Stability. The Journal of Physical Chemistry Letters. 2018, 9, 4638−4645
9. Xu Yinghua, Feng Xudong, Jia Jintong, Chen Xinyi, Jiang Tian, Rasool Aamir, Lv Bo, Qu Liangti, Li Chun*. A Novel β-Glucuronidase from Talaromyces pinophilus Li-93 Precisely Hydrolyzes Glycyrrhizin into Glycyrrhetinic Acid 3-O-Mono-β-d-Glucuronide. Applied and Environmental Microbiology, 2018,84(19):00755-18
10. Zhao Yujia, FanJingjing, Wang Chen, Feng Xudong*, Li Chun*. Enhancing oleanolic acid production in engineered Saccharomyces cerevisiae. Bioresource Technology.2018 (257) :339–343.
11. Yinghua Xu, Yanli Liu, Aamir Rasool, Wenwen E, Li Chun*. Sequence Editing Strategy for Improving Performance of β-glucuronidase from Aspergillus terreus. Chemical Engineering Science, 2017, 167: 145-153.
12. Yujia Zhao, Bo Lv, Xudong Feng*, Li Chun*. Perspective on Biotransformation and De Novo Biosynthesis of Licorice Constituents. Journal Agriculture Food Chemistry. 2017, 56(51): 14949-14958
13. Jia Haiyang, Sun Xiangying, Sun Huan, Li Chenyi, Wang Yunqian, Feng Xudong, Li Chun*. Intelligent Microbial Heat-Regulating Engine (IMHeRE) for Improved Thermo-Robustness and Efficiency of Bioconversion. ACS Synthetic Biology, 2016, 5(4): 321-320.
14. Aamir Rasool, Genlin Zhang, Zhe Li, Li Chun*. Engineering of Terpenoid Pathway in Saccharomyces cerevisiae Cooverproduce Squalene and Oleic acid. Chemical Engineering Science, 2016, 152:457-467
15. Xudong Feng, Heng Tang, Beijia Han, Bo Lv, Chun Li*. Engineering the thermostability of β-glucuronidase from Penicillium purpurogenum Li-3 by loop transplant. Applied Microbiology and Biotechnology, 2016. 100(23), 9955-9966
16. Zhang Genlin, Cao Qian, Liu Jingzhu, Liu Baiyang, Li Jun, Li Chun*. Refactoring ß-amyrin synthesis in Saccharomyces cerevisiae. AIChE Journal. 2015, 61(10): 3172-3179.
17. Li Zhe, Guo Xiaoxiao, Feng Xudong, Li Chun*. An environment friendly and efficient process for xylitol bioconversion from enzymatic corncob hydrolysate by adapted Candida tropicalis. Chemical Engineering Journal. 263 (2015) 249–256
18. Qiao Lifeng, Lv Bo, Feng Xudong, and Li Chun*. A new application of aptamer: One-step purification and immobilization of enzyme from cell lysates for biocatalysis. Journal of Biotechnology. 2015, 203: 68-76.
19. 王颖，李春*. 细胞工厂中的代谢传质与过程强化. 中国科学：生命科学，2017, 47: 544-553.
20. 朱明，王彩霞，李春*. 工程化酿酒酵母合成植物三萜类化合物. 化工学报，2015，66(9):3350-3356

联系方式：

清华大学化学工程系，英士楼407

北京100084，中国

电话：1510684649

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