潘俊敏

清华大学 生命科学学院

教授，博士生导师

研究经历 

1986年／河北师范大学／学士

1989年／中科院水生所／硕士 

1996年／德国弗莱堡大学／博士

1997－1999年／美国西南医学中心／博士后

2000－2006年／美国西南医学中心／研究助理教授

2006年-至今／清华大学生命科学学院／教授

研究兴趣、领域

主要有两个研究方向，纤毛生物学与微藻技术的开发和利用。纤毛行使细胞运动和信号传导的功能，其结构或功能缺陷与人类疾病相关。纤毛的组装和解聚涉及信号传导，细胞骨架的动态变化，蛋白质运输以及基因转录等，我们在模式生物衣藻和动物细胞中，利用遗传，细胞，生化和各种组学手段研究纤毛发生和解聚的机理，鉴定参与这些过程的重要基因的功能。在微藻技术方面，主要是开发微藻合成生物学工具以及研发潜在高价值的附加产物。

代表性论文

1.Zhu X, Wang J, Li S, Lechtreck K, Pan J*. 2021. IFT54 directly interacts with kinesin-II and IFT dynein to regulate anterograde intraflagellar transport. EMBO J 40: e105781.

2.Li S, Wan KY, Chen W, Tao H, Liang X*, Pan J*. 2020. Functional exploration of heterotrimeric kinesin-II in IFT and ciliary length control in Chlamydomonas. eLife 9:e58868.

3.Zhao Q, Li S, Shao S, Wang Z, Pan J*. 2020. FLS2 Is a CDK-like Kinase That Directly Binds IFT70 and Is Required for Proper Ciliary Disassembly in Chlamydomonas. Plos Genet. 16(3):e1008561

4.Liang Y, Zhu X, Wu Q, Pan J*. 2018. Ciliary Length Sensing Regulates IFT Entry via Changes in FLA8/KIF3B Phosphorylation to Control Ciliary Assembly. Curr Biol. 28(15), 2429-2435.

5.Zhu B, Zhu X, Wang L, Liang Y, Feng Q, Pan J*. 2017. Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis. PLoS Genet. 13(2):e1006627.

6.Hu J, Liang Y, He W, Pan J *. 2015. Cilia disassembly with two distinct phases of regulation. Cell Reports 10, 1803-1810.

7.Liang Y, Pang Y, Wu Q, Hu Z, Han X, Xu Y, Deng H, Pan J*. 2014. FLA8/KIF3B phosphorylation regulates kinesin-II interaction with IFT-B to control IFT entry and turnaround. Dev Cell. 30, 585-597.

8.Cao M, Meng D, Wang L, Bei S, Snell WJ*, Pan J*. 2013. Activation loop phosphorylation of a protein kinase is a molecular marker of organelle size that dynamically reports flagellar length. PNAS, 110, 12337-42.

联系方式

电话：+86-10-62771864

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通讯地址： 北京海淀清华大学生命学院, 邮编100084

齐天从

副教授，博士生导师

清华大学，生命科学学院

研究经历

2003 – 2007     中国农业大学, 学士

2007 – 2012     清华大学, 博士

2012 – 2016     清华大学, 博士后

2016 – 2019     美国加州大学伯克利分校, 唐氏杰出学者, 博士后

2019 – 2022     清华大学生命科学学院, 助理教授

2023-至今        清华大学生命科学学院, 副教授

研究方向

植物病虫害影响植物产量与品质，造成严重农业经济损失。实验室研究聚焦于植物与病原微生物互作的分子机理。我们综合运用细胞生物学、生物信息学与结构生物学等多学科手段，旨在解析植物的免疫信号通路与病原菌的致病机制。在此基础上，我们利用合成生物学等技术，进行抗病植物的理性设计与智能改造，为应对重大病虫害、推动作物育种与生产提供理论与技术支撑。

代表论文

1. Wang H, Song S, Gao S, Yu Q, Zhang H, Cui X, Fan J, Xin X, Liu Y, Staskawicz B, Qi T*. The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis. Plant Cell. 2024, 36(2):427-446. 
2. Xiao Y, Sun G, Yu Q, Gao T, Zhu Q, Wang R, Huang S, Han Z, Cervone F, Yin H, Qi T, Wang Y, Chai J. A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity. Science. 2024, 383(6684):732-739.
3. Song S*, Liu B, Song J, Pang S, Song T, Gao S, Zhang Y, Huang H, Qi T*. A molecular framework for signaling crosstalk between jasmonate and ethylene in anthocyanin biosynthesis, trichome development, and defenses against insect herbivores in Arabidopsis. J Integr Plant Biol. 2022,64(9):1770-1788.
4. Liu B, Seong K, Pang S, Song J, Gao H, Wang C, Zhai J, Zhang Y, Gao S, Li X, Qi T*, Song S*. Functional specificity, diversity and redundancy of Arabidopsis JAZ family repressors in jasmonate and COI1-regulated growth, development and defense. New Phytologist, 2021, 231(4):1525-1545. 
5. Song S*, Liu B, Zhai J, Zhang Y, Wang K, Qi T*. The intragenic suppressor mutation Leu59Phe compensates for the effect of detrimental mutations in the jasmonate receptor COI1. Plant Journal, 2021, 108(3):690-704. 
6. Martin R^#, Qi T^#, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ. Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ. Science, 2020, 370(6521):eabd9993.
7. Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai JS, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN, Kobe B. NAD⁺ cleavage activity by animal and plant TIR domains in cell death pathways.Science. 2019, 365(6455):793-799.
8. Qi T, Seong K, ThomazellaD, Kim JR, Pham J, Seo E, Cho MJ, Schultink A and Staskawicz B. NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana. PNAS, 2018, 115(46): E10979–
9. Wu D^#, Qi T^#, Li WX, Tian H, Gao H, Wang J, Ge J, Yao R, Ren C, Wang XB, Liu Y, Kang L, Ding SW, Xie D. Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Research, 2017, 27(3): 402–
10. Qi T, Huang H, Song S, Xie D. Regulation of jasmonate-mediated stamen development and seed production by a bHLH-MYB complex in Arabidopsis. Plant Cell, 2015,27(6): 1620–1633.
11. Qi T, Wang J, Huang H, Liu B, Gao H, Liu Y, Song S, Xie D. Regulation of jasmonate-induced leaf senescence by antagonism between bHLH subgroup IIIe and IIId factors in Arabidopsis. Plant Cell, 2015, 27(6): 1634–1649.
12. Qi T, Huang H, Wu D, Yan J, Qi Y, Song S, Xie D. Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy. Plant Cell, 2014, 26(3): 1118–
13. Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T^#, Xie D^#. Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis. Plant Cell, 2014, 26(1): 263–
14. Song S^#, Qi T^#, Fan M, Zhang X, Huang H, Gao H, Wu D, Guo H, Xie D. The bHLH subgroup IIId factors negatively regulate jasmonate-mediated plant defense and development. PLoS Genetics, 2013, 9(7): e1003653.
15. Qi T, Song S, Ren Q, Wu D, Huang H, Chen Y, Fan M, Peng W, Ren C, Xie D. The Jasmonate-ZIM-domain proteins interact with the WD-repeat/bHLH/MYB complexes to regulate jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana. Plant Cell, 2011, 23(5): 1795–

^#:Co-first author; *: Corresponding authors

联系方式

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卢磊

助理教授，博士生导师

清华大学，药学院

研究经历 

威斯康星大学-麦迪逊分校，美国 2014-2020  博士（药学与化学）

佐治亚理工大学， 美国 2019-2021硕士（计算机科学）

武汉大学 2012-2014硕士（药物工程）

武汉大学 2008-2012本科（药学）

研究方向

研究背景多元化， 在蛋白质从头设计、蛋白质组学、计算生物学及化学生物学等领域有多项研究成果， 发表于 Science、 Nature Methods 等杂志。未来的研究集中于使用糖蛋白质组学和蛋白设计的方法发展新型疾病监测与治疗的技术。

代表论文

1. Lu L, Gou X, Tan S, Man S, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti M, Ashworth A, Polizzi N, & DeGrado W. (2024) De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384,106-112.

2. Lu L, Scalf M, Shortreed M, Smith L. (2021) Mesh fragmentation improves dissociation

efficiency in top-down proteomics. Journal of the American Society for Mass Spectrometry, 23;32(6):1319-25.

3. Lu L*, Riley N*, Shortreed M, Bertozzi C & Smith L (2020). O-Pair Search with MetaMorpheus for O-glycopeptide Characterization. Nature Methods, 17, 1133-1138.

4. Zhong X, Yu Q, Ma F, Frost D, Lu L, Chen Z, Zetterberg H, Carlsson C, Okonkwo O & Li L. (2019). HOTMAQ: A Multiplexed Absolute Quantification Method for Targeted Proteomics. Analytical Chemistry, 91(3), 2112-2119.

5. Lu L, Millikin R, Solntsev S, Rolfs Z, Scalf M, Shortreed M, & Smith L. (2018). Identification of MS-cleavable and noncleavable chemically cross-linked peptides with MetaMorpheus. Journal of Proteome Research, 17(7), 2370-2376.

6. Li B, Li H, Lu L, & Jiang J. (2017). Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. Nature Structural & Molecular Biology, 24(4), 362.

7. Hu C, Worth M, Fan D, Li B, Li H, Lu L, Zhong X, Lin Z, Wei L, Ge Y and Li L, Jiang J.(2017). Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase. Nature Chemical Biology, 13(12), 1267.

8. Lu L, Fan D, Hu, C, Worth M, Ma Z, & Jiang J. (2016). Distributive O-GlcNAcylation on the highly repetitive C-terminal domain of RNA polymerase II. Biochemistry, 55(7), 1149-1158.

9. Zhu F, Lu L, Fu S, Zhong X, Hu M, Deng Z, & Liu T. (2015). Targeted engineering and scale up of lycopene overproduction in Escherichia coli. Process Biochemistry, 50(3), 341-346.

10. Liu Q, Wu K, Cheng Y, Lu L, Xiao E, Zhang Y, Deng Z and Liu T. (2015). Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. Metabolic Engineering, 28, 82-90.

11. Liu, R, Zhu F, Lu L, Fu A, Lu J, Deng Z, & Liu T. (2014). Metabolic engineering of fatty acylACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic Engineering, 22, 10-21.

12. Zhu F, Zhong X, Hu M, Lu L, Deng Z, & Liu T. (2014). In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. Biotechnology and Bioengineering, 111(7), 1396-1405.

联系方式

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