the-university-of-manchester-and-tsinghua-university-beijing-have-launched-a-new-dual-degree-phd-programme-in-synthetic-and-systems-biology

The programme builds on the collaborative agreement signed between the Manchester Institute of Biotechnology and Tsinghua University’s Centre for Synthetic and Systems Biology in 2016.

Students will benefit from the world-class academic supervision, facilities and research infrastructure of these two globally renowned universities.

Professor George Guoqiang Chen, the Programme Director of Tsinghua University, said: “This Tsinghua-Manchester dual degree PhD programme will provide unique opportunities for students to experience various research environments of both Universities, to learn great sciences across national borders and to become more culturally open. More importantly, the students will exploit complementary strengths of both sites. We expect students graduating from this programme to be much more competitive in the global market.”

The University of Manchester and Tsinghua University have had an ongoing relationship for many years, established initially in 2007 during the tenures of Professor Alan Gilbert and Professor Gu Binglin and formalised in January 2018 when the presidents of the two universities, Professor Dame Nancy Rothwell and Professor Yong Qiu, signed a Memorandum of Understanding.

Dr Neil Dixon, from Manchester’sDepartment of Chemistryhas been appointed Programme Director and will provide the academic leadership for its implementation and development. Speaking at the launch of the programme, Dr Dixon said: “This promises to be a fantastic programme and will provide a unique educational experience for the next generation of scientists. The strengths of Manchester and Tsinghua together will provide an excellent environment for PhD students to grow and blossom. The international outlook of the programme will provide the students with the skill set to address current and future global challenges.”

For more than ten years numerous research collaborations have been initiated, especially in Science and Engineering. The launch of this initiative represents a significant milestone in the development of the broader relationship between The University of Manchester and Tsinghua University.

Professor Martin Schröder, Vice President of The University of Manchester and Dean of theFaculty of Science and Engineeringstates: “The area of industrial biotechnology, embracing synthetic and systems biology, is a research beacon for The University of Manchester, representing a world-leading interdisciplinary activity with major funding and outstanding outputs and impact. This new collaboration with Tsinghua University will enable new routes to translation of research discoveries to the market-place to the benefit of all, and will also forge an important new relationship between the two Universities.”

The recruitment process is now underway and the first cohort of students will commence their studies from September 2020.

吴赴清

清华大学  副研究员

教育经历

1999.09-2003.07，西南农业大学 学士

2003.09-2009.06，中国农业大学 博士

2009.07-2012.12，中国农业科学院作科所，助理研究员

2013.01-2018.07，中国农业科学院作科所，副研究员

2018.08-至今，清华大学生命学院，副研究员

研究方向

（1）聚羟基脂肪酸酯医学应用研究

（2）嗜盐微生物抗盐碱机制解析及其应用

代表性论文

1.    Ma W^#, Wu F^#, Sheng P, Wang X, Zhang Z, Zhou K, Zhang H, Hu J, Lin Q, Cheng Z, Wang J, Zhu S, Zhang X, Guo X, Wang H, Wu C, Zhai H, Wan J. The LBD12-1 Transcription Factor Suppresses Apical Meristem Size by Repressing Argonaute 10 Expression. Plant Physiol. 2017 Jan;173(1):801-811.

2. Liu J, Chen J, Zheng X, Wu F, Lin Q, Heng Y, Tian P, Cheng Z, Yu X, Zhou K, Zhang X, Guo X, Wang J, Wang H, Wan J. GW5 acts in the brassinosteroid signaling pathway to regulate grain width and weight in rice. Nature Plants, 2017, 3, 17043

3.    Wang J^#, Wu F^#, Zhu S, Xu Y, Cheng Z, Wang J, Li C, Sheng P, Zhang H, Cai M, Guo X, Zhang X, Wang C, Wan J. Overexpression of OsMYB1R1-VP64 fusion protein increases grain yield in rice by delaying flowering time. FEBS Lett. 2016 Oct;590(19):3385-3396.

4.    Sheng P^#, Wu F^#, Tan J, Zhang H, Ma W, Chen L, Wang J, Wang J, Zhu S, Guo X, Wang J, Zhang X, Cheng Z, Bao Y, Wu C, Liu X, Wan J. CONSTANS-like transcriptional activator, OsCOL13, functions as a negative regulator of flowering downstream of OsphyB and upstream of Ehd1 in rice. Plant Mol Biol. 2016 Sep;92(1-2):209-22.

5.    Lin Q^#, Wu F^#, Sheng P, Zhang Z, Zhang X, Guo X, Wang J, Cheng Z, Wang J, Wang H, Wan J. The SnRK2-APC/CTE regulatory module mediates the antagonistic action of gibberellic acid and abscisic acid pathway in plants. Nature commun, 2015, 14, 6:7981 | DOI: 10.1038/ncomms8981 |

6.    Wu F^#, Sheng P^#, Tan J†, Chen X, Lu G, Ma W, Heng Y, Lin Q, Zhu S, Wang J, Wang J, Guo X, Zhang X, Lei C, Wan J. Plasma membrane receptor-like kinase leaf panicle 2 acts downstream of the DROUGHT AND SALT TOLERANCE transcription factor to regulate drought sensitivity in rice. J Exp Bot. 2015 Jan;66(1):271-81.

7.    Lu G^#, Wu F^#, Wu W, Wang H, Zheng X, Zhang Y, Chen X, Zhou K, Jin M, Cheng Z, Li X, Jiang L, Wang H, Wan J. Rice LTG1 is involved in adaptive growth and fitness under low ambient temperature. The Plant J. 2014, 78(3): 468–480

8.    Tan J^#, Tan Z^#, Wu F^#, Sheng P, Heng Y, Wang X, Ren Y, Wang J, Guo X, Zhang X, Cheng Z, Jiang L, Liu X, Wang H, Wan J. A Novel Chloroplast-Localized Pentatricopeptide Repeat Protein Involved in Splicing Affects Chloroplast Development and Abiotic Stress Response in Rice. Mol Plant. 2014, 7(8): 1329-1349

9.    Zhou F, Lin Q, Zhu L, Ren Y, Zhou K, Shabek N, Wu F, Mao H, Dong W, Gan L, Ma W, Gao H, Chen J, Yang C, Wang D, Tan J, Zhang X, Guo X, Wang J, Jiang L, Liu X, Chen W, Chu J, Yan C, Ueno K, Ito S, Asami T, Cheng Z, Wang J, Lei C, Zhai H, Wu C, Wang H, Zheng N, Wan J. D14-SCF(D3)-dependent degradation of D53 regulates strigolactone signalling. Nature. 2013 Dec 19; 504 (7480):406-10.

10.    Ma X^#, Cheng Z^#, Wu F^#, Jin M, Zhang L, Feng Zhou, Jiulin Wang, Kunneng Zhou, Jian Ma, Qibing Lin, Cailin Lei, Jianmin Wan. BEAK LIKE SPIKELET1 is Required for Lateral Development of Lemma and Palea in Rice. Plant Mol Biol Rep (2013) 31:98–108

11.    Wu F^#, Xin Q^#, Cao Z^#, Liu Z†, Du S, Mei C, Zhao C, Wang X, Shang Y, Jiang T, Zhang X, Yan L, Zhao R, Cui Z, Liu R, Sun H, Yang X, Su Z, Zhang D. The magnesium-chelatase H subunit binds abscisic acid and functions in abscisic acid signaling: new evidence in Arabidopsis. Plant Physiol. 2009 Aug;150(4):1940-54.

12.  Shen Y^#, Wang X^#, Wu F^#, Du S, Cao Z, Shang Y, Wang X, Peng C, Yu X, Zhu S, Fan R, Xu Y, Zhang D. The Mg-chelatase H subunit is an abscisic acid receptor. Nature. 2006 Oct 19;443(7113):823-6.

(^#Equal contributions)

联系方式：

电话：010－62772235(office)

邮箱：该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

李寅青

清华大学  研究员

博士生导师

教育经历

2008年 获复旦大学微电子系学士学位

2012年 获麻省理工学院获得电子工程与计算机专业硕士学位

2016年 获麻省理工学院获得电子工程与计算机专业博士学位

2016-2018年 博德研究所、斯坦利精神疾病中心完成博士后研究

2018-至今 清华大学任教

研究方向

复杂疾病的产生和发展往往伴随着一系列发生在分子和细胞层面的关键变化。诊断和治疗的主要挑战之一便是要清晰的理解在疾病的产生和发展过程中，哪个时间点上有哪些分子和细胞发生了关键变化，以及这些变化是如何影响细胞自身和细胞间互相作用的，并通过针对关键分子和细胞的编辑，实现对于疾病的控制。 李寅青博士的研究团队专注于基因组医学技术的三个重要方面的开发。 （1）单细胞表征技术。实现表观遗传组、转录组、信号组单细胞多组学，在时间和空间两个尺度上整体表征分子、细胞、细胞间作用的变化。 （2）基因编辑技术。探索新的编辑系统，基因替换和表观遗传控制，实现细胞从基因到状态的全面调控。 （3）生物信息学。发展与应用统计推断及机器学习算法，分析高通量数据和挖掘原核基因工具。

科学贡献

1、皮层-丘脑回路的单细胞多组学解析 2、单细胞核的转录组技术 3、CRISPR基因编辑工具的改造和特异性表征 4、哺乳动物细胞的合成生物学基因电路模块化构建

所获荣誉

2016年 国家优秀自费留学生，特别优秀奖 2016年 Wenner-Gren Fellowship 2013年 McGovern Institute Fellowship

代表性论文

1. Li Y, Weiss R., A Modular Approach to Building Complex Synthetic Circuits. Methods in Molecular Biology. 2017 pp. 231–248, DOI:10.1007/978-1-4939-7223-4_17.

2. Yan WX, Mirzazadeh R, Garnerone S, Scott D, Schneider MW, Kallas T, Custodio J, Wernersson E, Li Y, Gao L, Federova Y, Zetsche B, Zhang F, Bienko M, Crosetto N., BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks. NATURE COMMUNICATIONS. 2017, 8:15058.

3. Habib N*, Li Y*, Heidenreich M, Swiech L, Avraham-Davidi I, Trombetta JJ, Hession C, Zhang F, Regev A. Div-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons. SCIENCE. 2016, 353(6302):925-8.

4. Yamano T, Nishimasu H, Zetsche B, Hirano H, Slaymaker IM, Li Y, Fedorova I, Nakane T, Makarova KS, Koonin EV, Ishitani R, Zhang F, Nureki O. Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA. CELL. 2016, 165(4):949-62.

5. Nishimasu H, Cong L, Yan W, Ran F, Bernd Z, Li Y, Kurabayashi A, Ishitani R, Zhang F, Nureki O. Crystal structure of Staphylococcus aureus Cas9. CELL. 2015, 162(5):1113-26.

6. Davidsohn N, Beal J, Kiani S, Adler A, Yaman F, Li Y, Xie Z, Weiss R. Accurate predictions of genetic circuit behavior from part characterization and modular composition. ACS SYNTHETIC BIOLOGY. 2015, 4(6):673-81.

7. Li Y*, Jiang Y*, Chen H*, Liao W, Li Z, Weiss R, Xie Z. Modular construction of mammalian gene circuits using TALE transcriptional repressors. NATURE CHEMICAL BIOLOGY. 2015, 11(3):207-13.

8. Swiech L, Heidenreich M, Banerjee A, Habib N, Li Y, Trombetta J, Sur M, Zhang F. In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9. NATURE BIOTECHNOLOGY. 2015, 33(1):102-6.

9. Duportet X, Wroblewska L, Guye P, Li Y, Eyquem J, Rieders J, Rimchala T, Batt G, Weiss R. A platform for rapid prototyping of synthetic gene networks in mammalian cells. NUCLEIC ACIDS RESEARCH. 2014, 42(21):13440-51.

10. Busskamp V, Lewis NE, Guye P, Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J, Li Y, Li S, Stadler M, Weiss R, Church GM. Rapid neurogenesis through transcriptional activation in human stem cells. MOLECULAR SYSTEMS BIOLOGY. 2014, 10:760.

11. Kiani S, Beal J, Ebrahimkhani MR, Huh J, Hall RN, Xie Z, Li Y, Weiss R. CRISPR transcriptional repression devices and layered circuits in mammalian cells. NATURE METHODS. 2014, 11(7):723-6.

12. Hsu PD, Scott DA, Weinstein JA, Ran FA, Konermann S, Agarwala V, Li Y, Fine EJ, Wu X, Shalem O, Cradick TJ, Marraffini LA, Bao G, Zhang F. DNA targeting specificity of RNA-guided Cas9 nucleases. NATURE BIOTECHNOLOGY. 2013, 31(9):827-32.

13. Guye P*, Li Y*, Wroblewska L, Duportet X, Weiss R. Rapid, modular and reliable construction of complex mammalian gene circuits. NUCLEIC ACIDS RESEARCH. 2013, 41

(16):e156.

14. Sakar MS, Neal D, Boudou T, Borochin MA, Li Y, Weiss R, Kamm RD, Chen CS, Asada HH. Formation and optogenetic control of engineered 3D skeletal muscle bioactuators. LAB ON A CHIP. 2012, 12(23):4976-85.

15. Zhao P, Li Y, Zeng X, Zhou J, Huang Y, Liu R. EWOD using P(VDF-TrFE). IEEE Nano/Micro Engineered and Molecular Systems. 2009, 10.1109/NEMS.2009.5068559.

16. Zhao P, Li Y, Zhou J, Huang Y, Xie H, Xu H. A novel EWOD digital microuidic device using P(VDF-TrFE). IEEE Solid-State and Integrated-Circuit Technology. 2008, 10.1109/ICSICT.2008.4735080.

李寅青博士个人主页：http://web.mit.edu/yinqingl/www/

  “冷泉港亚洲——合成生物学”于11月28日到12月2日，在苏州独墅湖畔召开，参与者来自世界各地。陈国强，戴俊彪和谢震老师参加了此次会议，均作了口头报告；另外参会的6名学生作了口头报告或poster。

                               谢震老师介绍了利用合成生物学方法在哺乳动物细胞中优化 Cas-9 系统的作用；戴俊彪老师则介绍了酵母染色体合成过程中的一些合成生物学方法的探究和应用；陈国强老师的报告，则是对一种新的合成生物学底盘微生物——盐单胞菌的研究，并结合应用分析了盐单胞菌相较于目前常规底盘微生物的优势。 

               另外中心的三名同学——凌晨，叶健文和 Dina Elhadi均作了口头报告，三位同学的报告分别着重于理性设计，代谢工程和生产应用三个方面，体现了合成生物学从基础到应用的连续性。 

                在 poster环节中，中心两名同学获得了优秀墙报奖，戴俊彪老师实验室的罗周卿和陈国强老师实验室的陈祥斌同学分别获得第二和第一名；该奖只设4名，中心学生脱颖而出，展现了我们的风采。

        2016年10月11日上午清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所签署合作备忘录（Memorandum of Understanding）签字仪式在清华大学生物新馆举行。曼切斯特大学生物技术研究所主任Nigel S. Scrutton与清华大学合成与系统生物学中心主任陈国强代表双方完成签字仪式。

清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所MOU签字仪式

曼切斯特大学生物技术研究所主任Nigel S. Scrutton在作报告

      在签字仪式上，Nigel S. Scrutton主任介绍了曼切斯特大学生物技术研究所工作重点是酶家族称为”ene reduc-Tases”，这将涉及从基本了解酶的机制，物理学，量子生物学和先进的动力学方法，直到应用于生物催化，特别是用于生产单萜调味剂和香料的微生物的工程化。双方就合作领域将是生物技术/合成和系统生物学领域的科学和技术课题达成合作意向。

英国曼切斯特大学生物技术研究所：

      英国曼彻斯特生物技术研究所（MIB）以前是曼彻斯特跨学科生物中心。该中心的设计旨在使学术界能够探索跨学科定量生物科学的特定领域，主要是通过多学科研究团队的努力。 MIB的研究遵循三个广泛定义，跨学科和互补的主题：生物机制和催化，分子生物工程，系统生物学。

      该研究所的规划于1998年年底开始，最终于2006年10月25日的约翰·加西德大楼正式开幕。该研究所于2012年6月1日更名为曼彻斯特生物技术研究所，保留了首字母缩略词MIB。

 清华大学合成与系统生物学中心：

      清华大学合成与系统生物学中心骨干包括中科院院士1名、973首席4名、长江杰青8名（人次），优青1名、全国百篇1名。其中，主持了我国10项合成生物学973项目中的2项、以及唯一的生物信息学“973”项目。

       研究涉及高通量组学的生物信息学、复杂疾病的网络调控研究、表观基因组学及其遗传机制研究、化学品生物合成及代谢网络研究、基因线路构建及医药应用、基因合成与基因组组装、环境微生物及宏基因组学等研究领域。中心在国际学术界和国内外相关产业界有较好声誉，是国内最重要的合成生物学研究队伍之一。

Nigel S. Scrutton ScD FRSC FRSB,

Director, Manchester Institute of Biotechnology,

Director, Manchester Synthetic Biology Centre, SYNBIOCHEM,

Director, Marie Curie Innovative Doctoral Training Program, MAGIC

EPSRC Established Career Fellow,

Manchester Institute of Biotechnology

University of Manchester

Education background

University of Cambrige

Biography

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Nigel has an established position in the field of enzyme catalysis, biophysics and biomolecular engineering. He is recipient of the Biochemical Society Colworth Medal, the RSC Charmian Medal, the RSC Rita and John Cornforth Award and a Royal Society Wolfson Research Merit Award. He has served on several national steering groups, advisory boards and governing bodies. He heads a group of ca 40 researchers. He has published ca 380 scientific papers, holds several patents, and has edited 3 volumes on enzyme chemistry, quantum biology, biocatalysis, synthetic biology and engineering. He has held contiguous externally funded research fellowships for 29 years. Nigel is Director of the BBSRC/EPSRC Synthetic Biology Research Centre 'SYNBIOCHEM' based in MIB and Director of a Marie Curie IDP 'MAGIC' responsible for the training of 12 early stage researchers at Manchester. Nigel is also a Director of the MIB spin out company C3 Biotechnologies Ltd. He holds visiting professorships at Tsinghua University, China and University of Cardiff, UK.

Nigel’s group is noted internationally for its contributions to enzyme catalysis, especially in the fields of quantum biology (tunneling), protein dynamics and biocatalysis, and more recently synthetic biology in relation to chemicals production. His work is interdisciplinary at the interfaces of chemistry, biology and physics, supported by a genuinely world-leading infrastructure for biophysical chemistry that he has established at Manchester.

Contact　Information：

Director Manchester Institute of Biotechnology

Centre for Synthetic Biology 'SYNBIOCHEM'

Manchester Institute of Biotechnology

School of Chemistry

Faculty of Science and Engineering

The University of Manchester

131 Princess Street Manchester

M1 7DN

UK

Tel: +44 (0) 161 306 5152

Fax: +44 (0) 161 306 5199

Mobile: +44 7917 592392 

2016年10月11日上午清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所签署合作备忘录（Memorandum of Understanding）签字仪式在清华大学生物新馆举行。曼切斯特大学生物技术研究所主任Nigel S. Scrutton与清华大学合成与系统生物学中心主任陈国强代表双方完成签字仪式。

清华大学合成与系统生物学中心-英国曼切斯特大学生物技术研究所MOU签字仪式

曼切斯特大学生物技术研究所主任Nigel S. Scrutton在作报告

在签字仪式上，Nigel S. Scrutton主任介绍了曼切斯特大学生物技术研究所工作重点是酶家族称为”ene reduc-Tases”，这将涉及从基本了解酶的机制，物理学，量子生物学和先进的动力学方法，直到应用于生物催化，特别是用于生产单萜调味剂和香料的微生物的工程化。双方就合作领域将是生物技术/合成和系统生物学领域的科学和技术课题达成合作意向。

英国曼切斯特大学生物技术研究所：

英国曼彻斯特生物技术研究所（MIB）以前是曼彻斯特跨学科生物中心。该中心的设计旨在使学术界能够探索跨学科定量生物科学的特定领域，主要是通过多学科研究团队的努力。 MIB的研究遵循三个广泛定义，跨学科和互补的主题：生物机制和催化，分子生物工程，系统生物学。

该研究所的规划于1998年年底开始，最终于2006年10月25日的约翰·加西德大楼正式开幕。该研究所于2012年6月1日更名为曼彻斯特生物技术研究所，保留了首字母缩略词MIB。

 清华大学合成与系统生物学中心：

清华大学合成与系统生物学中心骨干包括中科院院士1名、千人计划1名、973首席4名、长江杰青8名（人次），青年千人计划8名、优青1名、全国百篇1名。其中，主持了我国10项合成生物学973项目中的2项、以及唯一的生物信息学“973”项目。

研究涉及高通量组学的生物信息学、复杂疾病的网络调控研究、表观基因组学及其遗传机制研究、化学品生物合成及代谢网络研究、基因线路构建及医药应用、基因合成与基因组组装、环境微生物及宏基因组学等研究领域。中心在国际学术界和国内外相关产业界有较好声誉，是国内最重要的合成生物学研究队伍之一。

Time: 9:30-11:00,  Oct 11st (Tuesday)

Venue: Room 143, New Biology Building, THU

Host: Dr. CHEN Guo-Qiang

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Abstract

 I have been fascinated by the complexity and catalytic capabilities of enzymes throughout my career. My group has pursued research on the mechanisms and structures of biocatalysts - and more recently on light-responsive proteins - and integrated these studies into ambitious synthetic biology and metabolic engineering programmes (e.g. for chemicals production). My group has undertaken ambitious, wide-ranging interdisciplinary programmes in experimental enzyme biophysics and integrated these with structural and chemical biology, computational simulation and theory. Highlights have included demonstration of the unexpected importance of nuclear tunneling mechanisms in biological catalysis, discovery of new biological cofactors (e.g. prenylated flavins), structures of enzymes in complex with lead drug compounds (e.g. for Huntington's chorea/Alzheimer's disease) and mechanistic understanding of new roles for vitamin B12 and other photoreceptors in light-activated transcriptional regulation. In the fields of metabolic engineering/synthetic biology/directed evolution we have engineered organisms to biosynthesize propane gas and a wide array of monoterpenoid products. These programmes have their foundations in basic discovery science and in selected cases extend to commercial exploitation through spin out activity.

In this lecture I will highlight selected aspects of our work focused on the enzyme family termed ‘ene reductases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances. The lecture will also highlight infrastructure and capabilities available in the Manchester Synthetic Biology Centre (SYNBIOCHEM) that I established recently and for which I am Director.

Time: 9:30-11:00,  Oct 11st (Tuesday)

Venue: Room 143, New Biology Building, THU

Host: Dr. CHEN Guo-Qiang

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Abstract

 I have been fascinated by the complexity and catalytic capabilities of enzymes throughout my career. My group has pursued research on the mechanisms and structures of biocatalysts - and more recently on light-responsive proteins - and integrated these studies into ambitious synthetic biology and metabolic engineering programmes (e.g. for chemicals production). My group has undertaken ambitious, wide-ranging interdisciplinary programmes in experimental enzyme biophysics and integrated these with structural and chemical biology, computational simulation and theory. Highlights have included demonstration of the unexpected importance of nuclear tunneling mechanisms in biological catalysis, discovery of new biological cofactors (e.g. prenylated flavins), structures of enzymes in complex with lead drug compounds (e.g. for Huntington's chorea/Alzheimer's disease) and mechanistic understanding of new roles for vitamin B12 and other photoreceptors in light-activated transcriptional regulation. In the fields of metabolic engineering/synthetic biology/directed evolution we have engineered organisms to biosynthesize propane gas and a wide array of monoterpenoid products. These programmes have their foundations in basic discovery science and in selected cases extend to commercial exploitation through spin out activity.

In this lecture I will highlight selected aspects of our work focused on the enzyme family termed ‘ene reductases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances. The lecture will also highlight infrastructure and capabilities available in the Manchester Synthetic Biology Centre (SYNBIOCHEM) that I established recently and for which I am Director.

时间：6.14-6.17

地点：北京，上海，深圳

注册参会链接：http://synbiobeta.com/conferences/synbiobeta-china-2016/

 该会议的重点是通过整合来自企业家、学术界、产业界、政策制定者、和投资者等之间的多方关系，来促进合成生物学在中国生态系统和产业化方面的发展。通过这次活动，您不仅可以与相关的行业领袖、学者、投资人、以及企业家建立一个交流切磋、合作共赢的关系网络，还可以了解到全球最新合成生物学产业的发展动向，新技术的开发及其应用等信息。

大会报告人来自不同国家（包括美国，英国和中国）的多个行业，包括生物医药和农业，重点讨论自动化工具（如CAD）的应用以及新的DNA合成方法等。

本次会议将会让以下几种合成生物学爱好者们受益匪浅：

•技术从业者

•工业和新兴创业公司

•政府机构及投资者

•高科技开发人员

•学术及科研人员

•学生和生物爱好者

通过参加这次活动，您会发现谁是率先在中国进行合成生物学产业化研究并将其商业化的领军人物，而且，您还会深入全面的了解到合成生物学的全球发展趋势，并有机会找到合作或投资的绝佳契机。