TIANCONG QI

 

 

TIANCONG QI

Tsinghua University, School of Life Sciences

 Principal Investigator

 

 

Education and work experience

2003 – 2007        B.S.A., China Agricultural University

2007 – 2012        Ph.D., Tsinghua University

2012 – 2016        Postdoctoral Scholar, Tsinghua University

2016 – 2019        Tang Distinguished Scholar, Postdoctoral Scholar, University of California, Berkeley

2019 – 2022        Assistant Professor, School of Life Sciences, Tsinghua University

2023 – now         Associate Professor, School of Life Sciences, Tsinghua University

 

Research interest

Plant diseases and pests significantly impact crop yield and quality, and have caused serious agricultural economic losses. Our laboratory focuses on investigating the molecular mechanisms underlying plant-pathogen interactions. We employ an integrated approach combining cell biology, bioinformatics, and structural biology to decipher plant immune signaling pathways and pathogenic mechanisms of pathogens. Building on these insights, we further apply synthetic biology technologies to rationally design and engineer disease-resistant plants, providing theoretical and technical support for addressing major crop diseases, and advancing crop breeding and agricultural production.

 

Selected publications

  1. Wang H, Song S, Gao S, Yu Q, Zhang H, Cui X, Fan J, Xin X, Liu Y, Staskawicz B, Qi T*. The NLR immune receptor ADR1 and lipase-like proteins EDS1 and PAD4 mediate stomatal immunity in Nicotiana benthamiana and Arabidopsis. Plant Cell. 2024, 36(2):427-446. 
  2. Xiao Y, Sun G, Yu Q, Gao T, Zhu Q, Wang R, Huang S, Han Z, Cervone F, Yin H, Qi T, Wang Y, Chai J. A plant mechanism of hijacking pathogen virulence factors to trigger innate immunity. Science. 2024, 383(6684):732-739.
  3. Song S*, Liu B, Song J, Pang S, Song T, Gao S, Zhang Y, Huang H, Qi T*. A molecular framework for signaling crosstalk between jasmonate and ethylene in anthocyanin biosynthesis, trichome development, and defenses against insect herbivores in Arabidopsis. J Integr Plant Biol. 2022,64(9):1770-1788.
  4. Liu B, Seong K, Pang S, Song J, Gao H, Wang C, Zhai J, Zhang Y, Gao S, Li X, Qi T*, Song S*. Functional specificity, diversity and redundancy of Arabidopsis JAZ family repressors in jasmonate and COI1-regulated growth, development and defense. New Phytologist, 2021, 231(4):1525-1545. 
  5. Song S*, Liu B, Zhai J, Zhang Y, Wang K, Qi T*. The intragenic suppressor mutation Leu59Phe compensates for the effect of detrimental mutations in the jasmonate receptor COI1. Plant Journal, 2021, 108(3):690-704. 
  6. Martin R#, Qi T#, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ. Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ. Science, 2020, 370(6521):eabd9993.
  7. Horsefield S, Burdett H, Zhang X, Manik MK, Shi Y, Chen J, Qi T, Gilley J, Lai JS, Rank MX, Casey LW, Gu W, Ericsson DJ, Foley G, Hughes RO, Bosanac T, von Itzstein M, Rathjen JP, Nanson JD, Boden M, Dry IB, Williams SJ, Staskawicz BJ, Coleman MP, Ve T, Dodds PN, Kobe B. NAD+ cleavage activity by animal and plant TIR domains in cell death pathways.Science. 2019, 365(6455):793-799.
  8. Qi T, Seong K, ThomazellaD, Kim JR, Pham J, Seo E, Cho MJ, Schultink A and Staskawicz B. NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana. PNAS, 2018, 115(46): E10979–
  9. Wu D#, Qi T#, Li WX, Tian H, Gao H, Wang J, Ge J, Yao R, Ren C, Wang XB, Liu Y, Kang L, Ding SW, Xie D. Viral effector protein manipulates host hormone signaling to attract insect vectors. Cell Research, 2017, 27(3): 402–
  10. Qi T, Huang H, Song S, Xie D. Regulation of jasmonate-mediated stamen development and seed production by a bHLH-MYB complex in Arabidopsis. Plant Cell, 2015,27(6): 1620–1633.
  11. Qi T, Wang J, Huang H, Liu B, Gao H, Liu Y, Song S, Xie D. Regulation of jasmonate-induced leaf senescence by antagonism between bHLH subgroup IIIe and IIId factors in Arabidopsis. Plant Cell, 2015, 27(6): 1634–1649.
  12. Qi T, Huang H, Wu D, Yan J, Qi Y, Song S, Xie D. Arabidopsis DELLA and JAZ proteins bind the WD-repeat/bHLH/MYB complex to modulate gibberellin and jasmonate signaling synergy. Plant Cell, 2014, 26(3): 1118–
  13. Song S, Huang H, Gao H, Wang J, Wu D, Liu X, Yang S, Zhai Q, Li C, Qi T#, Xie D#. Interaction between MYC2 and ETHYLENE INSENSITIVE3 modulates antagonism between jasmonate and ethylene signaling in Arabidopsis. Plant Cell, 2014, 26(1): 263–
  14. Song S#, Qi T#, Fan M, Zhang X, Huang H, Gao H, Wu D, Guo H, Xie D. The bHLH subgroup IIId factors negatively regulate jasmonate-mediated plant defense and development. PLoS Genetics, 2013, 9(7): e1003653.
  15. Qi T, Song S, Ren Q, Wu D, Huang H, Chen Y, Fan M, Peng W, Ren C, Xie D. The Jasmonate-ZIM-domain proteins interact with the WD-repeat/bHLH/MYB complexes to regulate jasmonate-mediated anthocyanin accumulation and trichome initiation in Arabidopsis thaliana. Plant Cell, 2011, 23(5): 1795–

#:Co-first author; *: Corresponding authors

 

Contact information

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