LEI LU
Assistant Professor
School of Pharmaceutical Sciences, Tsinghua University
EDUCATION
University of Wisconsin-Madison 2014-2020 Ph.D., Pharmaceutical Sciences
Georgia Institute of Technology 2019-2021 MS (online), Computer Science
Wuhan University, China 2012-2014 MS, Pharmaceutical Engineering
Wuhan University, China 2008-2012 BS, Pharmacy
HONORS AND AWARDS
Graduate Student Research Travel Award, Graduate School, UW-Madison 2019
Graduate Student Research Travel Award, Graduate School, UW-Madison 2018
Mern Keir University of Wisconsin Distinguished Graduate Fellowship, UW-Madison 2014
Outstanding Undergraduate Student Scholarships, WHU 2011
The State Ambition-Encouraging Scholarships, WHU 2010
PUBLICATIONS
1. Lu L, Gou X, Tan S, Man S, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti M, Ashworth A, Polizzi N, & DeGrado W. (2024) De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384,106-112.
2. Lu L, Scalf M, Shortreed M, Smith L. (2021) Mesh fragmentation improves dissociation efficiency in top-down proteomics. Journal of the American Society for Mass Spectrometry, 23;32(6):1319-25.
3. Lu L*, Riley N*, Shortreed M, Bertozzi C & Smith L (2020). O-Pair Search with MetaMorpheus for O-glycopeptide Characterization. Nature Methods, 17, 1133-1138.
4. Zhong X, Yu Q, Ma F, Frost D, Lu L, Chen Z, Zetterberg H, Carlsson C, Okonkwo O & Li L. (2019). HOTMAQ: A Multiplexed Absolute Quantification Method for Targeted Proteomics. Analytical Chemistry, 91(3), 2112-2119.
5. Lu L, Millikin R, Solntsev S, Rolfs Z, Scalf M, Shortreed M, & Smith L. (2018). Identification of MS-cleavable and noncleavable chemically cross-linked peptides with MetaMorpheus. Journal of Proteome Research, 17(7), 2370-2376.
6. Li B, Li H, Lu L, & Jiang J. (2017). Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. Nature Structural & Molecular Biology, 24(4), 362.
7. Hu C, Worth M, Fan D, Li B, Li H, Lu L, Zhong X, Lin Z, Wei L, Ge Y and Li L, Jiang J.(2017). Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase. Nature Chemical Biology, 13(12), 1267.
8. Lu L, Fan D, Hu, C, Worth M, Ma Z, & Jiang J. (2016). Distributive O-GlcNAcylation on the highly repetitive C-terminal domain of RNA polymerase II. Biochemistry, 55(7), 1149-1158.
9. Zhu F, Lu L, Fu S, Zhong X, Hu M, Deng Z, & Liu T. (2015). Targeted engineering and scale up of lycopene overproduction in Escherichia coli. Process Biochemistry, 50(3), 341-346.
10. Liu Q, Wu K, Cheng Y, Lu L, Xiao E, Zhang Y, Deng Z and Liu T. (2015). Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. Metabolic Engineering, 28, 82-90.
11. Liu, R, Zhu F, Lu L, Fu A, Lu J, Deng Z, & Liu T. (2014). Metabolic engineering of fatty acylACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic Engineering, 22, 10-21.
12. Zhu F, Zhong X, Hu M, Lu L, Deng Z, & Liu T. (2014). In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. Biotechnology and Bioengineering, 111(7), 1396-1405.
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