WEI QIN

 

 

WEI QIN

Assistant Professor

School of Pharmaceutical Sciences, Tsinghua University

 

 

Personal Profile

Dr. Wei Qin received his bachelor's degree from the School of Life Sciences at Beijing Institute of Technology in 2014. He earned his Ph.D. from the School of Interdisciplinary Sciences at Peking University in 2019, where he studied under Professors Chu Wang and Xing Chen. From 2019 to 2023, he conducted postdoctoral research at Stanford University under the mentorship of Professor Alice Y. Ting. In recent years, he has published multiple papers as first or corresponding author (including co-authorship) in journals such as Cell, Nat Methods, Nat Chem Biol, Nat Commun, JACS, Angew Chem Int Ed, and ACS Cent Sci. Dr. Qin Wei has received honors including MIT Technology Review China's 35 Under 35 (2023), National Overseas Talent, Beijing Outstanding Young Scientist, and Bayer Researcher Award. He serves as Chief Scientist for the National Key R&D Program Youth Project and leads research initiatives including the National Natural Science Foundation General Program, Major Research Program Cultivation Project, and Beijing National Center for Molecular Sciences Open Project. He is a committee member of the Systems Biomedical Engineering Committee at the Chinese Society for Biotechnology. He serves as a reviewer for multiple journals including Nat Biotechnol, Nat Methods, Nat Chem Biol, and Nat Commun.

 

Research interests

The Qin Lab is long dedicated to developing function-driven chemical biology tools and proteomics technologies with spatiotemporal dynamic resolution, to explore critical biological questions such as intercellular communication, organelle and biomolecular interactions, and post-translational modifications. Specific research directions include:

  1. Developing novel in vivo-compatible proximity labeling technologies to achieve tissue- and cell-specific spatiotemporal proteomics in vivo, and to explore spatiotemporal regulatory mechanisms such as intercellular protein communication, transient protein conformational changes, and protein synthesis and degradation.
  2. Developing novel chemical proteomics strategies to study organelle interactions and protein interactions with other biomolecules, and applying these strategies to elucidate potential regulatory mechanisms in neurodegenerative diseases.
  3. Conducting large-scale analysis of the dynamic regulation of post-translational modifications, and further mining novel post-translational modifications and their regulatory mechanisms.

 

Selected Publications

  1. Guo, HY.; Sun, XG.; Li, C.; Luo, YW.; Jiang, N.; Lu, WJ.; Zhang, ZJ.; Chen, YZ.; Yang, H.; Guo, HD.; Wu, ZF.; Qin, W.*, History recording and content mapping of inter-organelle contacts in living systems via CLAP-ID. Cell. Under review.
  2. Lu, W.#; Zhang, Y.#; Wang, P.; Ni, X.; Zhuang, S.*; Qin, W.*. Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase. Nat Commun. Revised. ( # co-first authors; * co-corresponding authors)
  3. Huang, M.#; Fu, J.#; Wang, P.#; Chen, B.#; Yuan, Q.#; Yu, J.; Wang, H.; Liu, Y.; Li, Z.; Wu, Y.; Ying, T.; Wu, Q.; Zhu, M.*; Qin, W.*; Li, Y.*. Nearly complete conversion of insertion-type indel enhances knock-in and facilitates endogenous biomolecular condensate analysis. Submitted. Cell Research. In press. (# co-first authors; * co-corresponding authors)
  4. Wang, W.#; Guo, H.#; Yan, X.#; Pan, X.; Wang, X.; Rong, Y.; Bai, Z.; Zhang, L.; Wu, Z.; Zhao, X.; Huang, W.; Qin, W.*; Chu, L.*. Silicon-rhodamine-enabled Identification (SeeID) for near-infrared light-controlled proximity labeling in vitro and in vivo. Nat Commun. 2025. (# co-first authors; * co-corresponding authors)
  5. Sun, X.#; Zhang, Y.#; Lu, W.#; Guo, H.#; He, G.; Luo, S.; Guo, H.; Zhang, Z.; Wang, W.; Chu, L.; Liu, X.; Qin, W.*, Precise and in vivo-compatible spatial proteomics via bioluminescence triggered photocatalytic proximity labeling. ACS Cent. Sci. 2025. (# EqualContribution)
  6. Zhang, ZJ.#; Wang, YK.#; Lu, WJ.; Wang, XF.; Guo, HY.; Pan, XZ.; Liu, ZY.; Wu, ZF.; Qin, W.*, Spatiotemporally-resolved mapping of extracellular proteomes via in vivo-compatible TyroID. Nat. Commun. 2025. (# EqualContribution)
  7. Sun, XG.#; Chen, Y.#; Yang, C.; Yang, S.; Lin, W.; Quan, BY.; Ding, Q.; Chen, X.*; Wang, C.*; Qin, W.*, Chemical recording of pump-specific drug efflux in living cells. Angew. Chem. Int. Ed. 2024. Sep 26:e202409282. (# EqualContribution)
  8. Qin, W.#; Cheah, J.S.#; Xu, C.; Messing, J., Freibaum, B.D., Boeynaems, S., Taylor, J.P., Udeshi, N.D., Carr, S.A., Ting, A.Y. Dynamic mapping of proteome trafficking within and between living cells by TransitID. Cell. 2023, 186 (15), 3307-3324. (# EqualContribution)
  9. Qin, W.; Samuel, M.A.; Carey, C.K.; Carr, S.A.; Ting, A.Y. Spatiotemporally-resolved mapping of RNA binding proteins via functional proximity labeling reveals a mitochondrial mRNA anchor promoting stress recovery. 2021, 12
  10. Qin, W. #; Cho, F.K. #; Cavanagh, P.E. #; Ting, A.Y. Deciphering Molecular Interactions by Proximity Labeling. . 2021, 18(# EqualContribution)
  11. Qin, W.#; Zhang, Y.#; Tang, H.; Liu D.; Chen, Y.; Liu, Y.; Wang, C. Chemoproteomic Profiling of Itaconylation by Bioorthogonal Probes in Inflammatory Macrophages. . 2020, 142(# co-first authors)
  12. Qin, W.; Qin, K.; Zhang, Y.; Jia, W.; Chen, Y.; Cheng, B.; Peng, L.; Chen, N.; Liu, Y.; Zhou, W.; Wang, YL.; Chen, X.*; Wang, C.*. S-glycosylation-based cysteine profiling reveals regulation of glycolysis by itaconate. Nat. Chem. Biol. 2019, 15 (10), 983-991. (* co-corresponding authors)
  13. Qin, W.#; Qin, K.#; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Wang, C.*; Chen, X.*. Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling. Angew. Chem. Int. Ed. 2018, 57 (7), 1817-1820. ( # co-first authors; * co-corresponding authors) (Selected as back cover and very important paper)
  14. Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.*; Chen, X.*. Quantitative Time-resolved Chemoproteomics Reveals that Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis. Proc. Natl. Acad. Sci. USA 2017, 114 (33), E6749-e6758. (* co-corresponding authors)

 

 

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