RUNZE MAO
Assistant Professor
Aug. 2024–present, Assistant professor | Tsinghua University, CHINA
Jan. 2021–Jun. 2024, Postdoc. | California Institute of Technology, USA Jan.
Advisor: Prof. Frances H. Arnold
Oct. 2020–Dec. 2020, Postdoc. | Swiss Federal Institute of Technology, Lausanne, Switzerland
Advisor: Prof. Xile Hu
Jul. 2016–Sep. 2020, Ph.D. | Chemistry | Swiss Federal Institute of Technology, Lausanne, Switzerland
Advisor: Prof. Xile Hu | Doctoral Program Thesis Distinction
Sep. 2013–Jul. 2016, M.S. | Chemical Biology | Peking University, China
Advisor: Prof. Xin-Shan Ye | Graduate Excellence Award
Sep. 2009–Jul. 2013, B.S. | Chemistry | Henan Normal University, China
Advisors: Profs. Gui-Rong Qu & Hai-Ming Guo | Undergraduate Excellence Award
Selected Publications
1. Liang, L.; Wang, Y. H.; Cui, C. X.; Deng, X. S.; Wang, S. L.; Guo, H. M.; Li, Y.; Niu, H. Y.; Mao, R.* NADH AnaloguesEnable Metal- and Light-Free Decarboxylative Functionalization. Angew. Chem. Int. Ed. 2024, e20241513
2. Mao, R.; Gao, S.; Qin, Z.; Wu, S. J.; Li, Z. Q. Arnold, F. H. Biocatalytic, Enantioenriched Primary Amination ofTertiary C–H Bonds. Nat. Catalysis. 2024, 7, 585.
3. Mao, R.; Arnold, F. H. An Engineered Enzyme Enables Stereoconvergent Alkylation of Alkene Mixtures. Nat.Synth. 2024, 3, 160.
4. Mao, R.; Taylor, D. M.; Wackelin, D. J.; Wu, S. J.; Sicinski, K. M.; Arnold, F. H. Biocatalytic, StereoconvergentAlkylation of (Z/E)-Trisubstituted Silyl Enol Ethers. Nat. Synth. 2024, 3, 256.
5. †Wackelin, D. J.; †Mao, R. (共同⼀作); Sicinski, K. M.; Zhao, Y.; Chen, K.; Arnold, F. H. Enzymatic Assembly ofDiverse Lactone Structures: An Intramolecular C–H Functionalization Strategy. J. Am. Chem. Soc. 2024, 146,1580. (†同等贡献).
6. Mao, R.; Wackelin, D. J.; Jamieson, C. S.; Rogge, T.; Gao, S.; Das, A.; Taylor, D. M.; Houk, K. N.; Arnold, F. H.Enantio- and Diastereoenriched Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes from (Z/E)-Trisubstituted Enol Acetates. J. Am. Chem. Soc. 2023, 145, 16176.
7. Mao, R.; Bera, S.; Turla, A. C.; Hu, X. Copper-Catalyzed Intermolecular Functionalization of Unactivated C(sp3)– H Bonds and Aliphatic Carboxylic Acids. J. Am. Chem. Soc. 2021, 143, 14667.
8. †Bera, S.; †Mao, R. (共同⼀作); Hu, X. Enantioselective C(sp3)–C(sp3) Cross-Coupling of Non-Activated AlkylElectrophiles via Nickel Hydride Catalysis. Nat. Chem. 2021, 13, 270. (†同等贡献).
9. Mao, R.; Bera, S.; Cheseaux, A.; Hu, X. Deoxygenative Trifluoromethylthiolation of Carboxylic Acids. Chem. Sci.2019, 10, 9555.
10. Mao, R.; Balon, J.; Hu, X. Decarboxylative C(sp3)–O Cross-Coupling. Angew. Chem., Int. Ed. 2018, 57, 13624.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.