生命学院刘万里实验室招聘博士后

实验室研究方向：

分子免疫学、细胞生物学、疫苗学。应用高速高分辨率的活细胞单分子荧光成像技术，并结合传统的免疫学、生物化学和生物物理研究手段，致力于淋巴细胞功能研究。正在开展的工作包括：（1）淋巴细胞活化的分子机制及调控机制的研究；（2）淋巴细胞异常活化导致的自身免疫疾病及淋巴癌和白血病的研究；（3）免疫记忆的分子机制；（4）淋巴细胞感受机械力的生物学；（5）病原微生物作用于淋巴细胞活化途径的免疫逃逸新机制；（6）构建基于上述知识的新型疫苗和新型抗体药物。

招聘岗位：博士后

应聘条件：

1.        具有生物学、基础医学、光电工程等相关专业博士学位；

2.        工作严谨条理、诚信、有责任心；具备良好的独立科研能力和英文写作阅读能力。

岗位待遇：

按照清华大学博士后管理规定执行，解决博士后期间的子女入托、入学问题；在清华大学博士后的标准薪酬基础上，对于具有优异学术发展潜力的博士后，我们将提供具有国际竞争力的特别资助以及其他相关待遇。

申请方式：

申请人请将一份详细的个人简历（包括推荐人联系方式）发送至该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

陈国强

清华大学 生命科学学院

教授，博士生导师

教育部长江学者特聘教授

教育经历

1985年      获华南理工大学学士学位

1989年      获奥地利格拉茨(Graz)工业大学博士学位

1990-1994年 英国诺丁汉(Notthingham)大学和加拿大阿尔伯达(Alberta)大学做博士后研究

1994年      被聘为清华大学副教授

1997年      聘为教授

研究方向

长期从事“微生物和生物材料”的研究。在国际学术期刊上共发表微生物技术和生物材料相关论文200多篇， Web of Sciences纪录论文被引用八千多次次(H指数为47)。获得授权专利30项，40个公开专利。开发的技术已经在数家公司用于大规模生产微生物塑料聚羟基脂肪酸酯PHA。

担任职务

清华大学合成与系统生物学中心主任

973“合成生物学”项目的首席科学家。

另担任下面国际国内学术期刊《Journal of Biotechnology》 、《Microbial Cell Factories》、《Biotechnology Journal》、《Plos One》和《中国生物工程学报》副主编。另担任《Current Opinions in Biotechnology》、《Applied Microbiology and Biotechnology》、《Biomaterials》、《Biomacromolecules》、《Artificial Cells, Blood Substitutes and Biotechnology》、《ACS Synthetic Biology》和《Asia Pacific Biotech News》编委 。

所获荣誉

教育部长江学者特聘教授、第八届中国青年科技奖、自然科学基金委国家杰出青年、纽伦堡国际发明奖、国家发明二等奖(排名第一)、谈家祯生命科学创新奖、茅以升科技奖、首届闵恩泽能源化工杰出贡献奖、候德傍化工创新奖和教育部高校青年教师奖等。曾连续6年获得清华大学学生“良师益友”的光荣称号，进入清华大学“良师益友”名人堂。连续7年获得清华大学高论文他引的“梅贻琦奖”。

代表论文

1. Dong CL, Webb WR, Peng Q, Tang JZ, Forsyth NR, El Haj AJ and Chen GQ. A 3D collagen hydrogels stem cell tissue engineered formulation basing on growth factor phospholipid complex loaded PHBHHx nanoparticles. Journal of Biomedical Materials Research Part A 103 (2015) 282-288
2. Yin Jin, Chen GQ. Halomonas spp, a Rising Star for Industrial Biotechnology. Biotechnology Advance 10.1016/j.biotechadv.2014.10.008 (2015)
3. Guo YY, Shi ZY, Fu XZ, Chen JC, Wu Q and Chen GQ. Enhance General Circular DNA Construction Efficiency by Circumventing Long-Standing Contradictions among Ligation/Assembly and Transformation Steps. Microbial Cell Factories 2015, 14:18
4. Yin J, Wang H, Gao X, Fu XZ, Wu Q and Chen GQ. Effects of chromosomal gene copy number and locations on polyhydroxyalkanoates synthesis by Escherichia coli and Halomonas Appl Microbiol Biotechnol 99 (2015) 5523–5534
5. Lv L, Ren YL, Chen JC, Wu Q and Chen GQ. Application of CRISPRi for Prokaryotic Metabolic Engineering Involving Multiple Genes, A Case Study: Controllable P(3HB-co-4HB) Biosynthesis. Metabolic Engineering 29 (2015) 160–168
6. Meng DC, Wang Ying, Shen Rui, Chen JC, Wu Q and Chen GQ. Production of Poly(3-Hydroxypropionate) and P(3_Hydroxybutyrate-co-3-Hydroxypropionate) from Glucose by Engineered coli. Metabolic Engineering 29 (2015) 189–195
7. Jiang XR, Wang H, Shen R, Chen GQ. Engineering the Bacterial Shapes for Enhanced Inclusion Bodies Accumulation. Metabolic Engineering 29 (2015) 227-237
8. Guo YK, Dong JK, Zhou T, Li TY, Zhang WM, Wang LH, Auxillos J, Shen Y, Luo YS, Zheng YJ, Lin JW, Chen GQ, Wu QY, Cai YZ, Dai J The design and construction of standard biological parts for metabolic engineering in Saccharomyces cerevisiae. Nucleic Acid Research (2015) e88.
9. Chen GQ, Hajnal I, Ma YM, Wu H, Ye JW. Engineering the bacterial synthesis mechanism for diversifying polyhydroxyalkanoates. Trends in Biotechnology 33 (2015) 565-574
10. Chen GQ, Hajnal I. The “PHAome”. Trends in Biotechnology 33 (2015) 559-564

联系方式

清华大学生命科学学院，生物新馆101

北京100084，中国

电话：+86-010-62783844

Email: 该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。

Kang, T., White, J. T., Xie, Z., Benenson, Y., Sontag, E., & Bleris, L. (2013). Reverse Engineering Validation using a Benchmark Synthetic Gene Circuit in Human Cells. ACS Synthetic Biology. doi:10.1021/sb300093y

Kashyap, N., Pham, B., Xie, Z., & Bleris, L. (2013). Transcripts for combined synthetic microRNA and gene delivery. Molecular bioSystems. doi:10.1039/c3mb70043g

Guo W, Chung, W-Y, Qian, M, Pellegrini, M, Zhang, MQ (2013). Characterizing the strand-specific distribution of non-CpG methylation in human pluripotent cells. NAR. In press.

Guo W, Fiziev P, Yan W, Cokus S, Sun X, Zhang MQ, Chen PY, Pellegrini M (2013) BS-Seeker2: a versatile aligning pipeline for bisulfite sequencing data. BMC Genomics. 2013 Nov 10;14(1):774.

Jiang R, Zhang X, Zhang MQ (2013) Basics of Bioinformatics: Lecture Notes of Graduate Summer School on Bioinformatics of China. Book, ISBN-10:3642389503, ISBN-13: 978-3642389504. Springer 2013 edition.

Chen Y, Ding Y, Yang L, Yu J, Liu G, Wang X, Zhang S, Yu D, Song L, Zhang H, Zhang C, Huo L, Huo C, Wang Y, Du Y, Zhang H, Zhang P, Na H, Xu S, Zhu Y, Xie Z, He T, Zhang Y, Wang G, Fan Z, Yang F, Liu H, Wang X, Zhang X, Zhang MQ, Li Y, Steinbüchel A, Fujimoto T, Cichello S, Yu J, Liu P. (2013) Integrated omics study delineates the dynamics of lipid droplets in Rhodococcus opacus PD630. NAR, [Epub ahead of print], PMID:24150943.

Tam KW, Zhang W, Soh J, Stastny V, Chen M, Sun H, Thu K, Rios JJ, Yang C, Marconett CN, Selamat SA, Laird-Offringa IA, Taguchi A, Hanash S, Shames D, Ma X, Zhang MQ, Lam WL, Gazdar A (2013) CDKN2A/p16 Inactivation Mechanisms and Their Relationship to Smoke Exposure and Molecular Features in Non-Small-Cell Lung Cancer. J Thorac Oncol. 8:1378-88. PMID:24077454.

Wu D, Gu J, Zhang MQ. (2013) FastDMA: An Infinium HumanMethylation450 Beadchip Analyzer. PLoS One. 2013 Sep 5;8(9):e74275. PMID:24040221.

Kim MV, Ouyang W, Liao W, Zhang MQ, Li MO. (2013) The transcription factor Foxo1 controls central-memory CD8+ T cell responses to infection. Immunity. 39:286-97. PMID:23924514.

Qin J, Li MJ, Wang P, Wong NS, Wong MP, Xia Z, Tsao GS, Zhang MQ, Wang J (2013) ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data. Mol. Cell. Proteomics, [PubMed – in process] PMID:23924514.

Zhou D, Wu D, Li Z, Qian M, Zhang MQ (2013) Population dynamics of cancer cells with cell-state conversions. Quant. Biol. 2:2095-4689. DOI: 10.1007/s40484-013-0014-2.

Xie W, Schultz M, Lister R, Hou Z, Rajagopal N, Ray P, Whitaker JW, Tiam S, Hawkins DR, Leung D, Yang H, Wang T, Swanson SA, Zhang J, Zhu Y, Lee AY, Kim A, Nery J, Urich MA, Kuan S, Yen C, Klugman S, Yu P, Suknuntha K, Propson NE, Chen H, Edsall LE, Wagner U, Li Y, Ye Z, Kulkarni A, Xuan Z, Chung W, Chi NC, Antosiewicz-Bourget J, Slukvin I, Stewart R, Zhang MQ, Wang W, Thomson JA, Eckert JR, Ren B (2013) Epigenomic Analysis of Multi-lineage Differentiation of Human Embryonic Stem Cells. Cell, 153:1134-48. PMID:23664764.

Wen-Yu Chung, Robert J. Schmitz, Tanya Biorac, Delia Ye, Miroslav Dudas, Gavin D. Meredith, Christopher C. Adams, Joseph R. Ecker and Michael Q. Zhang (2013) Constructing hepitypes: phasing local genotype and DNA methylation. JNSNE, In press.

May P, Liao W, Wu Y, Shuai B, McCombie WR, Zhang MQ, Liu QA (2013) The Effects of Carbon Dioxide and Temperature on microRNA Expressions in Arabidopsis Development. Nat. Comm. 4:2145. PMID:23900278.
Ma X, Wang YW, Zhang MQ, Gazdar AF (2013) DNA methylation data analysis and its application to cancer research. Epigenomics. 5:301-16. PMID:23750645.

Wu J, Anczuków O, Krainer AR, Zhang MQ*, Zhang C* (2013) OLego: fast and sensitive mapping of spliced mRNA-Seq reads using small seeds. Nucl. Acid. Res. 41:5149-5163. PMID:23571760.

Wang C, Zhang MQ, Zhang Z (2013) Computational identification of active enhancers in model organisms. Genomics, Proteomics Bioinformatics, pii:S1672-0229(13)00047-8. PMID:23685394.

Megha Rajaram; Jianping Zhang; Tim Wang; Cem Kuscu; Mamoru Kato; Vladimir Grubor; Robert Weil; Asluag Helland; Anne-Lise Borrenson-Dale; Kathleen Cho; Douglas A Levine; Alan N Houghton; Jedd D Wolchok; Lois Myeroff; Sanford D Markowitz; Michael Zhang; Alex Krasnitz; Robert Lucito; David Mu; Scott Powers (2013) Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS ONE, 8:e66264. PMID:23805207.

Jin Gu, Zhenyu Xuan. Inferring the perturbed microRNA regulatory networks in cancer using hierarchical gene co-expression signatures. PLoS ONE 2013, 8(11):e81032.

Dingming Wu, Jin Gu, Michael Zhang. FastDMA: An Infinium HumanMethylation450 Beadchip Analyzer. PLoS ONE 2013, 8(9):e74275.

Ting Wang, Jin Gu, Jun Yuan, Ran Tao, Yanda Li, Shao Li. Inferring pathway crosstalk networks using gene set co-expression signatures. Molecular BioSystems 2013, 9(7):1822-1888.

Rui Li, Tao Ma, Jin Gu, Xujun Liang, Shao Li. Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients. Scientific Reports 2013, 3:1543.

Feng Zeng, Rui Jiang, Ting Chen, PyroHMMsnp: a SNP caller for Ion Torrent and 454 sequencing data, Nucleic Acids Research, accepted, 2013.

Li R, Ma T, Gu J, Liang X, Li S. Imbalanced network biomarkers for traditional Chinese medicine Syndrome in gastritis patients. Scientific Reports 2013;3:1543.

Zhang B, Wang X, Li S. An integrative platform of TCM network pharmacology and its application on an herbal formula, Qing-Luo-Yin. Evidence-based.

Zhang B, Liu L, Zhao S, Wang X, Liu L, Li S. Vitexicarpin acts as a novel angiogenesis inhibitor and its target network. Evidence-based Complementary and Alternative Medicine 2013:278405.

Freeberg MA, Han T,Moresco JJ, Kong A, Yang YC2, Lu ZJ2, Yates JR, Kim JK. (2013) Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae. Genome Biology.

Kudron M, Niu W, Lu Z, Wang G, Gerstein M, Snyder M, Reinke V. (2013) Tissue-specific direct targets of Caenorhabditis elegans Rb/E2F dictate distinct somatic and germline programs. Genome Biology.

Matthew H Larson, Luke A Gilbert, Xiaowo Wang, Wendell A Lim, Jonathan S Weissman & Lei S Qi, CRISPR interference (CRISPRi) for sequence-specific control of gene expression, Nature Protocols, 2013; 8, 2180–2196.