Oct 11,2016, the center for Synthetic & Biology of Tsinghua University-the Manchester Institute of Biotechnology of Manchester University signed the Memorandum of Understanding. The signing ceremony was held in the new biology buillding of Tsinghua University. Nigel S. Scrutton, Director of the Institute of Biotechnologyof Manchester University, and Chen Guoqiang, Director of the Center for Synthetic and Systemic Biology, Tsinghua University, signed the MoU.

The ceremony of Signing collaborative agreement between MIB of Manchester Unive and CSSB of Tsinghua Uiv

Nigel S. Scrutton, director of the Institute for Biotechnology at the University of Manchester, is reporting

At the signing ceremony, Nigel highlighted selected aspects of our work focused on the enzyme family termed ‘ene reduc-tases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances.The area of cooperation will be in scientific and technical subjects in areas of biotechnology/synthetic & systems biology.

Manchester Institute of Biotechnology of Manchester University

The Manchester Institute of Biotechnology, formerly the Manchester Interdisciplinary Biocentre (MIB) is a research institute of the University of Manchester, England. The centre has been designed to enable academic communities to explore specific areas of interdisciplinary quantitative bioscience, largely through the efforts of multidisciplinary research teams. Research at MIB follows three broadly defined, interdisciplinary and complementary themes: Biological Mechanism and Catalysis, Molecular Bioengineering, Systems biology.

Planning for the institute began late in 1998 and culminated with the official opening on 25 October 2006 of the John Garside Building. The institute was renamed the Manchester Institute of Biotechnology on 1 June 2012, retaining the acronym MIB.

Center for Synthetic & Biology of Tsinghua University

The Center for Synthetic & Biology of Tsinghua University’s core staff including one member of Chinese Academy of Sciences, one member of the Project of Thousand Talents plans, four Chief of the Project of 973, eight person-times of the Project of Changjiang Fund for Distinguished Young Scholars, 8 members of Thousand Youth Talents Plan Project of Thousand Youth Talents, one member of the project of Distinguished Young Scholars, one member of the project of the National 100. Three of them are in charge of 2 out of 10 synthetic biology 973 projects, and the only bioinformatics "973" project.

Nigel S. Scrutton ScD FRSC FRSB,

Director, Manchester Institute of Biotechnology,

Director, Manchester Synthetic Biology Centre, SYNBIOCHEM,

Director, Marie Curie Innovative Doctoral Training Program, MAGIC

EPSRC Established Career Fellow,

Manchester Institute of Biotechnology

University of Manchester

Education background

University of Cambrige

Biography

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Nigel has an established position in the field of enzyme catalysis, biophysics and biomolecular engineering. He is recipient of the Biochemical Society Colworth Medal, the RSC Charmian Medal, the RSC Rita and John Cornforth Award and a Royal Society Wolfson Research Merit Award. He has served on several national steering groups, advisory boards and governing bodies. He heads a group of ca 40 researchers. He has published ca 380 scientific papers, holds several patents, and has edited 3 volumes on enzyme chemistry, quantum biology, biocatalysis, synthetic biology and engineering. He has held contiguous externally funded research fellowships for 29 years. Nigel is Director of the BBSRC/EPSRC Synthetic Biology Research Centre 'SYNBIOCHEM' based in MIB and Director of a Marie Curie IDP 'MAGIC' responsible for the training of 12 early stage researchers at Manchester. Nigel is also a Director of the MIB spin out company C3 Biotechnologies Ltd. He holds visiting professorships at Tsinghua University, China and University of Cardiff, UK.

Nigel’s group is noted internationally for its contributions to enzyme catalysis, especially in the fields of quantum biology (tunneling), protein dynamics and biocatalysis, and more recently synthetic biology in relation to chemicals production. His work is interdisciplinary at the interfaces of chemistry, biology and physics, supported by a genuinely world-leading infrastructure for biophysical chemistry that he has established at Manchester.

Contact　Information：

Director Manchester Institute of Biotechnology

Centre for Synthetic Biology 'SYNBIOCHEM'

Manchester Institute of Biotechnology

School of Chemistry

Faculty of Science and Engineering

The University of Manchester

131 Princess Street Manchester

M1 7DN

UK

Tel: +44 (0) 161 306 5152

Fax: +44 (0) 161 306 5199

Mobile: +44 7917 592392 

Oct 11,2016, the center for Synthetic & Biology of Tsinghua University-the Manchester Institute of Biotechnology of Manchester University signed the Memorandum of Understanding. The signing ceremony was held in the new biology buillding of Tsinghua University. Nigel S. Scrutton, Director of the Institute of Biotechnologyof Manchester University, and Chen Guoqiang, Director of the Center for Synthetic and Systemic Biology, Tsinghua University, signed the MoU.

The ceremony of Signing collaborative agreement between MIB of Manchester Unive and CSSB of Tsinghua Uiv

Nigel S. Scrutton, director of the Institute for Biotechnology at the University of Manchester, is reporting

At the signing ceremony, Nigel highlighted selected aspects of our work focused on the enzyme family termed ‘ene reduc-tases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances.The area of cooperation will be in scientific and technical subjects in areas of biotechnology/synthetic & systems biology.

Manchester Institute of Biotechnology of Manchester University

The Manchester Institute of Biotechnology, formerly the Manchester Interdisciplinary Biocentre (MIB) is a research institute of the University of Manchester, England. The centre has been designed to enable academic communities to explore specific areas of interdisciplinary quantitative bioscience, largely through the efforts of multidisciplinary research teams. Research at MIB follows three broadly defined, interdisciplinary and complementary themes: Biological Mechanism and Catalysis, Molecular Bioengineering, Systems biology.

Planning for the institute began late in 1998 and culminated with the official opening on 25 October 2006 of the John Garside Building. The institute was renamed the Manchester Institute of Biotechnology on 1 June 2012, retaining the acronym MIB.

Center for Synthetic & Biology of Tsinghua University

The Center for Synthetic & Biology of Tsinghua University’s core staff including one member of Chinese Academy of Sciences, one member of the Project of Thousand Talents plans, four Chief of the Project of 973, eight person-times of the Project of Changjiang Fund for Distinguished Young Scholars, 8 members of Thousand Youth Talents Plan Project of Thousand Youth Talents, one member of the project of Distinguished Young Scholars, one member of the project of the National 100. Three of them are in charge of 2 out of 10 synthetic biology 973 projects, and the only bioinformatics "973" project.

Time: 9:30-11:00,  Oct 11st (Tuesday)

Venue: Room 143, New Biology Building, THU

Host: Dr. CHEN Guo-Qiang

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Abstract

 I have been fascinated by the complexity and catalytic capabilities of enzymes throughout my career. My group has pursued research on the mechanisms and structures of biocatalysts - and more recently on light-responsive proteins - and integrated these studies into ambitious synthetic biology and metabolic engineering programmes (e.g. for chemicals production). My group has undertaken ambitious, wide-ranging interdisciplinary programmes in experimental enzyme biophysics and integrated these with structural and chemical biology, computational simulation and theory. Highlights have included demonstration of the unexpected importance of nuclear tunneling mechanisms in biological catalysis, discovery of new biological cofactors (e.g. prenylated flavins), structures of enzymes in complex with lead drug compounds (e.g. for Huntington's chorea/Alzheimer's disease) and mechanistic understanding of new roles for vitamin B12 and other photoreceptors in light-activated transcriptional regulation. In the fields of metabolic engineering/synthetic biology/directed evolution we have engineered organisms to biosynthesize propane gas and a wide array of monoterpenoid products. These programmes have their foundations in basic discovery science and in selected cases extend to commercial exploitation through spin out activity.

In this lecture I will highlight selected aspects of our work focused on the enzyme family termed ‘ene reductases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances. The lecture will also highlight infrastructure and capabilities available in the Manchester Synthetic Biology Centre (SYNBIOCHEM) that I established recently and for which I am Director.

Time: 9:30-11:00,  Oct 11st (Tuesday)

Venue: Room 143, New Biology Building, THU

Host: Dr. CHEN Guo-Qiang

Nigel Scrutton is Director of the Manchester Institute of Biotechnology (MIB) at the University of Manchester, UK. He is responsible for the strategic leadership and operational management of the institute, which comprises over 50 leading research groups (ca 500 research staff) from across all Faculties and is home to ca £100M of current grant funding and 8 spin out companies. Nigel gained his PhD (1988; as a Benefactors' Scholar) and ScD (2003) at the University of Cambridge where he was awarded the Henry Humphrey's Research Prize. At Cambridge he held a Royal Society University Research Fellowship, a Royal Commission for the Exhibition of 1851 Fellowship and college fellowships. He was appointed Professor at the University of Manchester in 2005, where he held a BBSRC Professorial Research Fellowship and was Research Dean prior to his appointment as MIB Director. He also held academic positions (1995-2005) at the University of Leicester UK prior to taking up his current position at Manchester. He currently holds an EPSRC senior fellowship.

Abstract

 I have been fascinated by the complexity and catalytic capabilities of enzymes throughout my career. My group has pursued research on the mechanisms and structures of biocatalysts - and more recently on light-responsive proteins - and integrated these studies into ambitious synthetic biology and metabolic engineering programmes (e.g. for chemicals production). My group has undertaken ambitious, wide-ranging interdisciplinary programmes in experimental enzyme biophysics and integrated these with structural and chemical biology, computational simulation and theory. Highlights have included demonstration of the unexpected importance of nuclear tunneling mechanisms in biological catalysis, discovery of new biological cofactors (e.g. prenylated flavins), structures of enzymes in complex with lead drug compounds (e.g. for Huntington's chorea/Alzheimer's disease) and mechanistic understanding of new roles for vitamin B12 and other photoreceptors in light-activated transcriptional regulation. In the fields of metabolic engineering/synthetic biology/directed evolution we have engineered organisms to biosynthesize propane gas and a wide array of monoterpenoid products. These programmes have their foundations in basic discovery science and in selected cases extend to commercial exploitation through spin out activity.

In this lecture I will highlight selected aspects of our work focused on the enzyme family termed ‘ene reductases’. This will involve a journey from basic understanding of enzyme mechanisms, taking in structural biology, quantum biology and advanced kinetic methods, through to applications in biocatalysis, and ultimately to the engineering of microbial organisms for the production of monoterpene flavours and fragrances. The lecture will also highlight infrastructure and capabilities available in the Manchester Synthetic Biology Centre (SYNBIOCHEM) that I established recently and for which I am Director.

时间：6.14-6.17

地点：北京，上海，深圳

注册参会链接：http://synbiobeta.com/conferences/synbiobeta-china-2016/

 该会议的重点是通过整合来自企业家、学术界、产业界、政策制定者、和投资者等之间的多方关系，来促进合成生物学在中国生态系统和产业化方面的发展。通过这次活动，您不仅可以与相关的行业领袖、学者、投资人、以及企业家建立一个交流切磋、合作共赢的关系网络，还可以了解到全球最新合成生物学产业的发展动向，新技术的开发及其应用等信息。

大会报告人来自不同国家（包括美国，英国和中国）的多个行业，包括生物医药和农业，重点讨论自动化工具（如CAD）的应用以及新的DNA合成方法等。

本次会议将会让以下几种合成生物学爱好者们受益匪浅：

•技术从业者

•工业和新兴创业公司

•政府机构及投资者

•高科技开发人员

•学术及科研人员

•学生和生物爱好者

通过参加这次活动，您会发现谁是率先在中国进行合成生物学产业化研究并将其商业化的领军人物，而且，您还会深入全面的了解到合成生物学的全球发展趋势，并有机会找到合作或投资的绝佳契机。

2016年5月16日，生命学院朱听课题组与化学系刘磊课题组合作在Nature Chemistry杂志在线发表了题为 “A synthetic molecular system capable of mirror-image genetic replication and transcription”《合成镜像生物分子系统实现遗传信息复制与转录》的论文。该论文首次通过化学合成镜像聚合酶实现了中心法则中DNA的复制与转录这两个关键步骤。Nature在线新闻同步报道并评述了该研究。

原文链接：http://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2517.html

Nature新闻链接：http://www.nature.com/news/mirror-image-enzyme-copies-looking-glass-dna-1.19918

地球上已知所有生物都具有手性均一的特征，即构成生命的蛋白质几乎均由L型氨基酸组成，而DNA和RNA均由D型核糖组成；迄今为止还没有证据表明反手性生命系统在进化中曾经出现过。生命学院朱听课题组与化学系刘磊课题组合作，用化学合成方法构建了基于镜像ASFV pol X聚合酶的遗传信息复制与转录系统。该研究结果表明镜像DNA的复制与转录同样遵循碱基互补配对原则，并具有良好的手性特异性。由该镜像分子系统聚合得到的镜像DNA核酶实现了与天然DNA核酶相同的自剪切功能。该研究有望被用来聚合实用反手性核酸大分子，同时也向实现构建镜像生命系统迈出了重要的一步。

朱听课题组致力于合成生物学、基因组学研究。本文第一作者为生命学院2013级硕士研究生王子谋和化学系博士后徐维亮，通讯作者为生命学院朱听研究员和化学系刘磊教授。本课题得到国家自然科学基金委、科技部、清华大学自主科研计划、清华-北大生命科学联合中心、感染性疾病诊治协同创新中心的经费支持。

May 17th, 2016

Room 101，Yingshi Building, Department of Chemical Engineering

Tsinghua University, Beijing, China

Biological technology is becoming essential platform for healthcare,green industry, low carbon economy and sustainable society. Aiming at promotion of the mutual exchange and cooperation for scientific research and technology development, 2016 Tsinghua-EMBL Forum on Advanced Biological Technology (THE-FAB’2016) will be held in Tsinghua University, Beijing, China, from May 16th to 19th, 2016. THEFAB’ 2016 is jointly organized by Tsinghua University, China, and European Molecular Biology Laboratory (EMBL), Germany. Scope of THE-FAB’2016 will cover the academic research activities and technology transfer in pioneering biological technologies from biomolecules to cellular systems. This Forum will also provide an opportunity for mutual exchange of technology transformation based on basic research for both sides.

Organizers

Tsinghua University

European Molecular Biology Laboratory (EMBL)

Key Lab of Industrial Biocatalysis, Ministry of Education

Sponsor

XIN Center, Tsinghua University

Forum Chairpersons

Prof. Xin-Hui Xing Tsinghua University

Dr. Silke Schumacher EMBL

Important dates for the symposium

1) First circular: March 8th, 2016,

2) April 30th, 2016, abstract submission deadline

3) April 15th, 2016, Invitation letter (including materials for visa application if required)

4) May 1st, 2016, second circular, and the symposium program

AGENDA ON MAY 17TH, 2016

Place: Room 101, Yingshi Building, Tsinghua University

Contact information

Dr. Nan Su

Department of Chemical Engineering,

Tsinghua University, Beijing 100084, PRC.

Tel: +86-10-6277-3004 -806

Cell phone number: +86-18610372509

Fax: +86-10-6277-0304

This email address is being protected from spambots. You need JavaScript enabled to view it.

Dr. Shanshan Du

Department of Chemical Engineering,

Tsinghua University, Beijing 100084, PRC.

Tel: +86-10-6277-3004 -806

Cell phone number: +86-13011090989

Fax: +86-10-6277-0304

This email address is being protected from spambots. You need JavaScript enabled to view it.

Curriculum Vitae of Speakers:

ZhiJie Chang (Tsinghua Univ)

George Guo-Qiang Chen (Tsinghua Univ)

XinHui Xing((Tsinghua Univ)

Ye Xiang(Tsinghua Univ)  

YanMei Li(Tsinghua Univ)

Qi Jiang(Tsinghua Univ)

Jun Ma (Tsinghua Univ)

Xiao Jun Lu(Tsinghua Univ)

Matthias Wilmanns(EMBL)

Rob Meijers(EMBL)

Henning Hermjakob（EMBL-EBI ）

Jürgen Bauer (EMBLEM）

Charles E. Cook (EMBL)

Plamena Markova, LL.M(EMBL))

Dr. Silke Schumacher(EMBL)

清华附中生物竞赛班高一的十几位同学表示对合成生物学有兴趣，希望到中心的PI实验室学习。同学们选择了感兴趣的实验室。

中心相关的PI实验室在尽量培养同学们的兴趣的基础上给予更多的知识和帮助。同学们在新的环境下经过老师的辅导都有很大的进步。

老师们希望通过大家努力关照好这几位同学，他们都将是我们生命科学的的接班人，继承者。

清华大学鲁志课题组（RNA生物信息学实验室）招聘博士后

        本实验室专注于癌症和植物逆境胁迫相关研究，通过基因组学、生物信息学和遗传学方法发现癌症以及植物胁迫信号转导过程中的新型标记物，特别是新型的长链非编码RNA。我们通过最新一代的大规模测序技术和生物信息学分析，发现了很多重要的新型非编码基因，现在需要增加癌症和植物方面基础较好的成员加入我们进行更深入的研究，该人才可以是偏计算分析的计算背景人才，也可以是偏遗传学实验的湿实验人才。

应聘条件

1. 生物信息计算背景博士后（1-2名）

A 在生物信息、生物计算、大数据挖掘等方面有特长和经验。

B 有较强独立从事课题研究的能力，并以第一作者身份在国际杂志上发表影响因子超过4分的研究论文。

C 有植物或者癌症研究经验者优先。

2. 遗传学湿实验背景博士后（1-2名）

A 在遗传学方面有系统的知识和训练，对基因或非编码RNA的功能及其生物调控具有强烈兴趣。熟悉相关分子实验技术和细胞实验技术（如RNA i 等）。

B 有较强独立从事课题研究的能力，并以第一作者身份在国际杂志上发表影响因子超过4分的研究论文。

C 有植物或者癌症研究经验者优先。

岗位待遇：

清华大学博士后的标准福利待遇。优秀博士后可申请清华大学-北京大学生命科学联合中心“postdoctoral fellowship program”，提供具有国际竞争力的待遇和科研资助。

应聘者将本人简历以及可以开始工作的时间通过电子邮件发至：This email address is being protected from spambots. You need JavaScript enabled to view it.

email主题请标注“应聘生物信息博士后”或者“应聘湿实验博士后”，并注明招聘信息来源，谢谢。