卢磊
助理教授，博士生导师
清华大学，药学院
研究经历
威斯康星大学-麦迪逊分校，美国 2014-2020 博士（药学与化学）
佐治亚理工大学， 美国 2019-2021硕士（计算机科学）
武汉大学 2012-2014硕士（药物工程）
武汉大学 2008-2012本科（药学）
研究方向
研究背景多元化， 在蛋白质从头设计、蛋白质组学、计算生物学及化学生物学等领域有多项研究成果， 发表于 Science、 Nature Methods 等杂志。未来的研究集中于使用糖蛋白质组学和蛋白设计的方法发展新型疾病监测与治疗的技术。
代表论文
1. Lu L, Gou X, Tan S, Man S, Yang H, Zhong X, Gazgalis D, Valdiviezo J, Jo H, Wu Y, Diolaiti M, Ashworth A, Polizzi N, & DeGrado W. (2024) De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384,106-112.
2. Lu L, Scalf M, Shortreed M, Smith L. (2021) Mesh fragmentation improves dissociation
efficiency in top-down proteomics. Journal of the American Society for Mass Spectrometry, 23;32(6):1319-25.
3. Lu L*, Riley N*, Shortreed M, Bertozzi C & Smith L (2020). O-Pair Search with MetaMorpheus for O-glycopeptide Characterization. Nature Methods, 17, 1133-1138.
4. Zhong X, Yu Q, Ma F, Frost D, Lu L, Chen Z, Zetterberg H, Carlsson C, Okonkwo O & Li L. (2019). HOTMAQ: A Multiplexed Absolute Quantification Method for Targeted Proteomics. Analytical Chemistry, 91(3), 2112-2119.
5. Lu L, Millikin R, Solntsev S, Rolfs Z, Scalf M, Shortreed M, & Smith L. (2018). Identification of MS-cleavable and noncleavable chemically cross-linked peptides with MetaMorpheus. Journal of Proteome Research, 17(7), 2370-2376.
6. Li B, Li H, Lu L, & Jiang J. (2017). Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode. Nature Structural & Molecular Biology, 24(4), 362.
7. Hu C, Worth M, Fan D, Li B, Li H, Lu L, Zhong X, Lin Z, Wei L, Ge Y and Li L, Jiang J.(2017). Electrophilic probes for deciphering substrate recognition by O-GlcNAc transferase. Nature Chemical Biology, 13(12), 1267.
8. Lu L, Fan D, Hu, C, Worth M, Ma Z, & Jiang J. (2016). Distributive O-GlcNAcylation on the highly repetitive C-terminal domain of RNA polymerase II. Biochemistry, 55(7), 1149-1158.
9. Zhu F, Lu L, Fu S, Zhong X, Hu M, Deng Z, & Liu T. (2015). Targeted engineering and scale up of lycopene overproduction in Escherichia coli. Process Biochemistry, 50(3), 341-346.
10. Liu Q, Wu K, Cheng Y, Lu L, Xiao E, Zhang Y, Deng Z and Liu T. (2015). Engineering an iterative polyketide pathway in Escherichia coli results in single-form alkene and alkane overproduction. Metabolic Engineering, 28, 82-90.
11. Liu, R, Zhu F, Lu L, Fu A, Lu J, Deng Z, & Liu T. (2014). Metabolic engineering of fatty acylACP reductase-dependent pathway to improve fatty alcohol production in Escherichia coli. Metabolic Engineering, 22, 10-21.
12. Zhu F, Zhong X, Hu M, Lu L, Deng Z, & Liu T. (2014). In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. Biotechnology and Bioengineering, 111(7), 1396-1405.
联系方式
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