刘凯
清华大学化学系
教授,特聘研究员,博士生导师
国家杰青,首席科学家
工作及教育经历:
2020-至今 清华大学化学系长聘副教授、特聘研究员、博导
生命有机磷化学及化学生物学教育部重点实验室固定成员
有机光电子与分子工程教育部重点实验室固定成员
清华大学合成与系统生物学研究中心核心成员
2017-2020 中科院长春应化所稀土资源利用国家重点实验室 研究员、博导
2015-2017 荷兰格罗宁根大学、美国哈佛大学 博士后
2010-2015 荷兰格罗宁根大学Zernike先进材料研究所 博士学位
奖励与荣誉:
国家杰出青年科学基金(2021)
GF科技创新展讲解专家(2021)
中国生物技术创新大会青年人才优秀团队奖(2020)
中国工程院院刊Engineering优秀青年通讯专家(2020)
中国稀土十大科技新闻(2020)
国家重点项目首席科学家(2019)
中国青年化学家元素周期表(2019)
中科院卢嘉锡国际人才团队(2018)
吉林省青年科技奖(2018)
中科院长春分院青年先锋(2018)
国家海外高层次青年人才计划(2017)
荷兰NWO-Rubicon海外人才项目(2016)
荷兰优秀博士论文(Cum Laude,2015)
国家优秀自费留学生奖(2015)
学术兼职:
ACS Applied Bio Materials编委(2022-)
GF生物交叉领域专家(2019-)
科技部国家重点研发计划会评专家(2019-)
中国工程院院刊Engineering通讯专家/客座编辑(2019-)
温州市政府科技顾问(2019-)
中国生物物理学会纳米生物学分会委员(2019-)
中科院仪器装备研制项目专家(2018-)
中国化学会《应用化学》编委(2018-)
Current Nanomedicine编委(2018-)
吉林省青年科协理事(2018-)
研究方向:
研究方向为生物合成活性物质及高技术应用,尤其聚焦于高性能、可编程生物大分子(DNA、蛋白)及稀土杂合系统的生物合成及转化应用。构建了系列特种材料及其力学性能可编程性和对大创伤动态修复功能;建立了力学蛋白纳米组装新方法,并发展了鲁棒性纳米蛋白诊疗试剂;实现了生物活性分子超高密度信息编码和对大数据存储应用。截止2021年10月,在Sci. Adv.,PNAS,Nat. Commun.,Angew. Chem.,JACS,Adv. Mater.,Chem. Soc. Rev.,Acc. Chem. Res.等期刊发表论文110余篇。专利申请40项,授权18项,多项正在落地转化。
近三年代表性论文:
1,Z. Meng, Q. Liu, Y. Zhang, J. Sun, C. Yang, H. Li, M. Loznik, R. Göstl, D. Chen, F. Wang*, N. A. Clark, H. Zhang, A. Herrmann*, K. Liu*, Highly stiff and stretchable DNA liquid crystalline organogels with super plasticity, ultrafast self-healing and magnetic response behaviors, Adv. Mater. 2021, 33, 2106208.
2,J. Sun, L. Xiao, B. Li, K. Zhao, Z. Wang, Y. Zhou, C. Ma, J. Li, H. Zhang, A. Herrmann*, K. Liu*, Genetically engineered polypeptide adhesive coacervates for surgical applications, Angew. Chem. Int. Ed., 2021, 60, 23687.
3,L. Xiao, Z. Wang, Y. Sun, B. Li, B. Wu, C. Ma, V. S. Petrovskii, X. Gu, D. Chen, I. I. Potemkin, A. Herrmann, H. Zhang, K. Liu*, An artificial phase‐transitional underwater bioglue with robust and switchable adhesion performance, Angew. Chem. Int. Ed. 2021, 60, 12082.
4,C. Ma, B. Li, J. Zhang, Y. Sun, J. Li, H. Zhou, J. Shen, R. Gu, J. Qian, C. Fan, H. Zhang, K. Liu*, Significantly improving the bioefficacy for rheumatoid arthritis with supramolecular nanoformulations, Adv. Mater. 2021, 33, 2100098.
5,S. Wang, B. Li, H. Zhang, J. Chen, X. Sun, J. Xu, T. Ren, Y. Zhang, C. Ma*, W. Guo*, K. Liu*, Improving Bioavailaibity of Hydrophobic Prodrugs through Supramolecular Nanocarriers based on Recombinant Proteins for Osteosarcoma Treatment, Angew. Chem. Int. Ed. 2021, 60, 11252.
6,C. Ma, J. Sun, B. Li, Y. Feng, Y. Sun, L. Xiang, B. Wu, L. Xiao, B. Liu, V. S. Petrovskii, B. Liu, J. Zhang, Z. Wang, H. Li, L. Zhang, J. Li, F. Wang, R. Gostl, I. I. Potemkin, D. Chen, H. Zeng, H. Zhang, D. Weitz, K. Liu*, A. Herrmann*, Ultra-strong bio-glue from genetically engineered polypeptides, Nat. Commun. 2021, 12, 3613.
7,J. Sun, C. Ma, S. Maity, F. Wang, Y. Zhou, G. Portale, R. Göstl, W. H. Roos, H. Zhang, K. Liu*, A. Herrmann*, Reversibly photo-modulating mechanical stiffness and toughness of bioengineered protein fibers, Angew. Chem. Int. Ed. 2021, 60, 3222.
8,J. Sun, C. Ma, B. Li, F. Wang, K. Liu*, H. Zhang, Proteinaceous fibers with outstanding mechanical properties manipulated by supramolecular interactions, CCS Chem. 2020, 2, 1669.
9,C. Ma, B. Li, B. Shao, B. Wu, D. Chen, J. Su*, H. Zhang, K. Liu*, Anisotropic protein organofibers encoded with extraordinary mechanical behaviors for cellular mechanobiology applications, Angew. Chem., Int. Ed. 2020, 59, 21481.
10,C. Ma, J. Dong, M. Viviani, I. Tulini, N. Pontillo, S. Maity, Y. Zhou, W. H. Roos, K. Liu*, A. Herrmann*, G. Portale*, Denovo rational design of a freestanding, supercharged polypeptide, proton conducting membrane, Sci. Adv. 2020, 6, eabc0810.
11,J. Li#, Y. Sun#, Y. Liang#, J. Ma*, B. Li, C. Ma, R. Tanzi, H. Zhang, K. Liu*, C. Zhang*, Extracellular elastin molecule modulates Alzheimer’s Aβ dynamics in vitro and in vivo by affecting microglial activities, CCS Chem. 2020, 2, 1830.
12,B. Shao, S. Wan, C. Yang, J. Shen, Y. Li, H. You, D. Chen*, C. Fan, K. Liu*, H. Zhang*, Engineered Anisotropic Fluids of Rare Earth Nanomaterials, Angew. Chem., Int. Ed. 2020, 59, 18213.
13,Y. Zhang, L. Kong, F. Wang, B. Li, C. Ma, D. Chen*, K. Liu*, C. Fan, H. Zhang, Information stored in nanoscale: encoding data in a single DNA strand with Base64, Nano Today 2020, 33, 100871.
14,Y. Li, J. Li, J. Sun, H. He, B. Li, C. Ma, K. Liu*, H. Zhang, Bio-inspired and Mechanically Strong Fibers Based on Engineered Non-Spider Chimeric Proteins, Angew. Chem. Int. Ed. 2020, 59, 8148.
15,J. Li, B. Li, J. Sun, C. Ma, S. Wan, Y. Li, R. Göstl, A. Herrmann, K. Liu*, H. Zhang, Engineered Near-Infrared Fluorescent Protein Assemblies for Robust Bioimaging and Therapeutic Applications, Adv. Mater. 2020, 32, 2000964.
16,H. He, C. Yang, F. Wang*, Z. Wei, J. Shen, D. Chen, C. Fan, H. Zhang, K. Liu*, Mechanically strong globular protein-based fibers via microfluidic spinning technique, Angew. Chem. Int. Ed. 2020, 59, 4344.
17,Z. Sun, C. Yang, F. Wang, B. Wu, B. Shao, Z. Li, D. Chen*, Z. Yang*, K. Liu*, Biocompatible and pH‐Responsive Colloidal Surfactants with Tunable Shape for Controlled Interfacial Curvature, Angew. Chem. Int. Ed. 2020, 59, 9365.
18,C. Ma, J. Su, B. Li, A. Herrmann, H. Zhang, K. Liu*, Solvent-free plasticity and programmable mechanical behaviors of engineered proteins, Adv. Mater. 2020, 32, 1907697.
19,J. Sun, J. Su, C. Ma, R. Göstl, A. Herrmann, K. Liu*, H. Zhang,Fabrication and mechanical properties of engineered protein-based adhesives and fibers, Adv. Mater. 2020, 32, 1906360.
20,C.Ma, J. Su, Y. Sun, Y. Feng, N. Shen, B. Li, Y. Liang, X. Yang, H. Wu, H. Zhang, A. Herrmann*, R. E. Tanzi, K. Liu*, C. Zhang*, Significant upregulation of Alzheimer’s β-amyloids in vivo induced by extracellular elastin polypeptides, Angew. Chem. Int. Ed. 2019, 58, 18703.
21,H. He, K. Zhao, L. Xiao, Y. Zhang, Y. Cheng, S. Chen, L. Zhang*, X. Zhou*, K. Liu*, H. Zhang, Detection and chiral recognition of α-hydroxyl acid through proton and CEST NMR using Yb macrocyclic complex, Angew. Chem. Int. Ed. 2019, 58, 18286.
22,L. Zhang, C. Ma, J. Sun, B. Shao, D. Chen, G. Portale, K. Liu*, A. Herrmann*, Genetically engineered supercharged polypeptide fluids: fast and persistent self-ordering induced by a touch, Angew. Chem. Int. Ed. 2018. 57, 6878.
联系方式:
清华大学化学系, 生物医学馆D-207
北京100084,中国
电话:+86-010-62791893
Email:该Email地址已收到反垃圾邮件插件保护。要显示它您需要在浏览器中启用JavaScript。