梁琼麟 

清华大学   化学系

教授， 博士生导师

工作履历

学术兼职

研究领域

药物分析，药品质量与安全，中药现代化

研究概况

以微流控芯片及其与质谱、光谱联用分析技术为基础，发展生命分析与药物分析新方法，开发生物医用新材料新器件，发明器官类器官芯片新模型，致力于服务国家药品质量与安全、新药创制以及中药现代化研究与开发。近年来重点聚焦于器官类器官芯片、单细胞亚细胞分析及基于质谱的多组学分析等。曾主持完成国家重大科技专项第一个微流控芯片药物研发关键技术项目，在器官芯片核心关键技术及血管、肝、肾、肠等器官芯片模型研究方面取得重要进展。2016-2020年间以第一发明人申请发明专利16项（授权8项），以通讯作者在Nat. Protoc., Adv. Mater., Anal. Chem., Lab Chip等重要学术期刊上发表SCI论文59篇（14篇IF>10）。工作以来累计发表SCI论文180余篇，Web of Science引用5000余次，发明专利30余项。部分研究成果已在制药企业、临床医院得到广泛应用，曾合作获得国家科技进步二等奖3项。

成果奖励

2018世界中医药学会联合会中医药国际贡献奖（2/10）

2016国家科技进步二等奖（3/10）

2015中华中医药学会科学技术进步一等奖(3/15)

2014国家科技进步二等奖(8/10)

2013广西科技进步二等奖（6/10）

2012北京市科技进步二等奖（4/10）

2007国家科学技术进步二等奖(7/10)

学术论文（Selected Recent Publications）

1. Xie RX, Liang Z, Ai YJ, Zheng WC, Xiong JL, Xu PD, Liu YP, Ding MY, Gao JY, Wang Jiaping, and Liang QL*. Composable microfluidic spinning platforms for facile production of biomimetic perfusable hydrogel microtubes. Nature Protocols 2020, 15, doi.org/10.1038/s41596-020-00442-9
2. Xie RX, Korolj A, Liu C, Song X, Lu R, Zhang BY, Ramachandran A, Liang QL*, Radisic M*. h-FIBER: Microfluidic topographical hollow fiber for studies of glomerular filtration barrier. ACS Central Science 2020, 6, 903-912, doi.org/10.1021/acscentsci.9b01097
3. Xie RX, Zheng WC, Guan LD, Ai YJ, Liang QL*. Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues. Small 2020, 16(15), 1902838.
4. Ai YJ, Xie RX, Xiong JL, Liang QL*. Microfluidics for Biosynthesizing: from Droplets and Vesicles to Artificial Cells. Small2020, 16(9),1903940.
5. Xiong Jl, Xie RX, Wang Y, Wang CL, Ai YJ, Zheng WC, Ding MY, Gao JY, Wang JP, and Liang QL*. Nitrite-Responsive Hydrogel: Smart Drug Release Depending on the Severity of the Nitric Oxide-Related Disease. ACS Appl. Mater. Inter. 2020,12, 51185
6. Li JF, Liu L, Ai YJ, Liu Y, Sun HB*, Liang QL*. Self-Polymerized Dopamine-Decorated Au NPs and Coordinated with Fe-MOF as a Dual Binding Sites and Dual Signal-Amplifying Electrochemical Aptasensor for the Detection of CEA. ACS Applied Materials & Interfaces2020,12(5), 5500-5510
7. Ai YJ, Hu ZN, Liu L, Zhou JJ, Long Y, Li JF, Ding MY, Sun HB*, Liang QL*. Magnetically Hollow Pt Nanocages with Ultrathin Walls as a Highly Integrated Nanoreactor for Catalytic Transfer Hydrogenation Reaction. Advanced Science2019, 6 (7), 1802132.
8. Wang Y, Shao ZX, Zheng WC, Xie YY, Luo GA, Ding MY, Liang QL*. A 3D construct of the intestinal canal with wrinkle morphology on a centrifugation configuring microfluidic chip. Biofabrication2019, 11 (4), 045001.
9. Ai YJ, Zhang F, Wang CL, Xie RX, Liang QL*. Recent progress in lab-on-a-chip for pharmaceutical analysis and pharmacological/toxicological test. TrAC-Trends in Analytical Chemistry2019, 117, 215-230.
10. Xie RX, Xu PD, Liu YP, Li LL, Luo GA, Ding MY and Liang QL*. Necklace-Like Microfibers with Variable Knots and Perfusable Channels Fabricated by an Oil-Free Microfluidic Spinning Process. Advanced Materials, 2018, 30, 1705082.
11. Zhang F, Xiong LG, Ai YJ, Liang Z and Liang QL*. Stretchable Multi-responsive Hydrogel with Actuatable, Shape memory and Self-healing Properties. Advanced Science, 2018, 5, 1800450.
12. Li LL, Li YQ, Shao ZX, Luo GA, Ding MY and Liang QL*. Simultaneous Assay of Oxygen-Dependent Cytotoxicity and Genotoxicity of Anticancer Drugs on an Integrated Microchip.Analytical Chemistry, 2018,90(20), 11899-11907.
13. Ma LD, Wang YT, Wang JR, Wu JL, Meng XS, Hu P, Mu X, Liang QL* and Luo GA*. Design and Fabrication of a Liver-on-a-chip Platform for Convenient, Highly Efficient, and Safe in Situ Perfusion Culture of 3D Hepatic Spheroids. Lab on a Chip, 2018, 18, 2547 -2562.
14. Yang SH, Zhang FF, Liang QL* and Wang ZH*. A Three-Dimensional Graphene-Based Ratiometric Signal Amplification Apta sensor for MUC1 Detection. Biosensors & Bioelectronics, 2018, 120, 85-92.
15. Yang SH, Zhang FF, Wang ZH* and Liang QL*. A Graphene Oxide-based Label-free Electrochemical Aptasensor for the Detection of Alpha-fetoprotein. Biosensors & Bioelectronics, 2018, 112, 186-192.
16. Ai YJ, He MQ, Zhang F, Long Y, Li YZ, Han Q, Ding MY, Sun HB* and Liang QL*. Metallo-supramolecular Polymer Engineered Porous Carbon Framework Encapsulated Stable Ultra-small Nanoparticles: a General Approach to Construct Highly Dispersed Catalysts.Journal of Materials Chemistry A, 2018, 6, 16680-16689.
17. Long Y, Han Q, Yang ZQ, Ai YJ, Sun SA, Wang Y, Liang QL* and Ding MY*. A Novel Solvent-free Strategy for the Synthesis of Bismuth Oxyhalides. Journal of Materials Chemistry A, 2018, 6, 13005-13011.
18. Xu PD, Xie RX, Liu YP, Li LL, Luo GA, Ding MY and Liang QL*. Bioinspired Microfibers with Embedded Perfusable Helical Channels. Advanced Materials, 2017, 29, 1701664.
19. Zhou BJ, Li YZ, Niu GL, Lan MH, Jia QY, Liang QL*. Near-Infrared Organic Dye-Based Nanoagent for the Photothermal Therapy of Cancer. ACS Applied Materials & Interfaces, 2016, 8, 29899-29905.
20. Li LL, Wang WX, Ding MY, Luo GA and Liang QL*. Single-Cell-Arrayed Agarose Chip for in Situ Analysis of Cytotoxicity and Genotoxicity of DNA Cross-Linking Agents. Analytical Chemistry, 2016, 88, 6734-6742.

联系方式

清华大学化学系

北京100084，中国

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Fax. 86-10-62772263

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