Nian Liu
Tsinghua University
School of Life Sciences
Assistant Professor
2023-present Associate Professor, School of Life Sciences, Tsinghua University
2019-2023 Assistant Professor, School of Life Sciences, Tsinghua University
2015-2019 Postdoc, Department of Chemical & Systems Biology, Stanford University
2010-2015 Ph.D. in Chemistry, Department of Chemistry,
The University of Chicago – Chicago, USA
2006-2010 B.Sc. in Polymer Chemistry, Department of Polymer Science and Engineering,
University of Science & Technology of China – Hefei, China
Research Interest：
2024 Benyuan Fund – Young Investigator Exploration Fellowship In Life Sciences
2024 Outstanding Youth in Beijing
2020 Bayer Investigator Award
2016 Jane Coffin Childs Fund Fellowship
2016 RNA Society/Scaringe Graduate Student Award
2016 Award for Outstanding Self-financed Students Abroad
2015 Aldrich Alfred R. Bader Award for Student Innovation
Selected Publications:
1. Li X#, Bie L#, Wang Y#, Hong Y#, Zhou Z, Fan Y, Yan X, Tao Y, Huang C, Zhang Y, Sun X, Li J, Zhang J, Chang Z, Xi Q, Meng A, Shen X, Xie W, Liu N*. LINE-1 transcription activates long-range gene expression. Nature Genetics 56, 1494-1502 (2024).News & Views by: Liang, Y., Wang, T. LINE1 mediates long-range DNA interactions. Nature Genetics 56, 1328–1330 (2024).
2. Hong Y#, Bie L#, Zhang T#, Yan X, Jin G, Chen Z, Wang Y, Li X, Pei G, Zhang Y, Hong Y, Gong L, Li P, Xie W, Zhu Y, Shen X, Liu N*. SAFB restricts contact domain boundaries associated with L1 chimeric transcription. Molecular Cell 84, 598-615 (2024).
3. Wang D, Yan K, Yu H, Li H, Zhou W, Hong Y, Guo S, Wang Y, Xu Chen, Pan C, Tang Y, Liu N, Wu W, Zhang L*, Xi Q*. Fimepinostat impairs NFκB and PI3K/AKT signaling and enhances gemcitabine efficacy in H3K27M-mutated diffuse intrinsic pontine glioma. Cancer Research. 84(4), p. 598-615 (2024).
4. Li Y, Yang J, Shen S, Wang W, Liu N, Guo H*, Wei W*. SARS-CoV-2-encoded inhibitors of human LINE-1 retrotransposition. Journal of Medical Virology DOI: 10.1002/jmv.28135 (2022).
5. Zuo F#, Jiang J#, Fu H#, Yan K, Liefke R, Zhang J, Hong Y, Chang Z, Liu N, Wang Z*, Xi Q*. A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells. Cell Stem Cell 29 (6), 948-961 (2022).
6. Liu, N.#, Lee, C.#, Swigut, T., Grow, E., Gu, B., Bassik, M., and Wysocka, J. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Nature 553, 228-232 (2018).
7. Liu, N., Dai, Q., Zheng, G., He, C., Parisien, M., Pan, T. N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions. Nature 518, 560-564 (2015).News & Views by: Theler, D., Allain, FT. RNA modification does a regulatory two-step. Nature 518, 492–493 (2015).
8. Liu, N.*, Pan, T.* N6-methyladenosine-coded RNA Epigenetics. Nature Structural & Molecular Biology 23, 98-102 (2016).
9. Liu, N.#, Zhou, K.#, Parisien, M., Dai, Q., Diatchenko, L., and Pan, T. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Research 45 (10), 6051-6063 (2017).
10. Liu, N., Parisien, M., Dai, Q., Zheng, G., He, C., and Pan, T. Probing N6-methyl-adenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. RNA 19, 1848-1856 (2013).
Contect:
Lab page: http://liulab.life.tsinghua.edu.cn/
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
Address: LIU Nian Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China.