Chao MA

Tsinghua University

Department of Chemistry

Associate Professor

Dr. Ma has pioneered enabling technologies of synthetic biology and created new biomanufacturing fashion based on functional protein molecular machines, generating disruptive research from sustainability to regeneration. He has published more than 60 papers in key academic journals: four papers with corresponding authorships, including 1 in Angew. Chem. and 1 in Adv. Mater; ten papers with first authorships, including 1 in Sci. Adv. , 1 in Nat. Commun, 4 in Angew. Chem. and 4 in Adv. Mater. He also received funding from the National Excellent Young Scholar Science Program, and serves as the project leader of National Key Research and Development Program for Young Scientists, and of the Joint Fund for Young Talents of the Ministry of Education. In addition, he has been awarded by Beijing Nova Scholar Program and the Eagle Talent Program of Zhongguancun. 

Publications

1. Xin Zhang, Jingjing Li, Chao Ma*, Hongjie Zhang, Kai Liu*, Biomimetic Structural Proteins: Modular Assembly and High Mechanical Performance, Acc. Chem. Res., 2023, 56, 2664–2675.

2. Huijing Cui, Xin Zhang, Jing Chen, Xining Qian, Yuewen Zhong, Chao Ma*, Hongjie Zhang, Kai Liu*, The Construction of Microbial Synthesis System for Rare Earth Enrichment and Material Applications, Adv. Mater., 2023, 35, 2303457.

3. Xiaoyuan Zhao, Xiang Li, Bo Li, Yao Sun, Yejiao Shi, Huaxing Shen, Fan Wang, Jingjing Li, Farukh Sharopov, Zainiddin Mukhiddinov, Chao Ma*, Kai Liu*, Hong-Gang Hu*, A robust protein-peptide co-assembling nanoformulation (PePCAN) platform with significant cell-entry characteristics for targeted cancer therapy, Chem. Eng. J., 2023, 543, 139886.

4. Shidong Wang, Bo Li, Hongliang Zhang, Jiayin Chen, Xin Sun, Jie Xu, Tingting Ren, Yuanyuan Zhang, Chao Ma*, Wei Guo*, Kai Liu*, Improving Bioavailaibity of Hydrophobic Prodrugs through Supramolecular Nanocarriers Based on Recombinant Proteins for Osteosarcoma Treatment. Angew. Chem. Int. Ed., 2021, 60(20), 11252-11256.

5. Chao Ma#, Jing Sun#, Bo Li#, Yang Feng, Yao Sun, Li Xiang, Baiheng Wu, Lingling Xiao, Baimei Liu, Vladislav S. Petrovskii, Bin Liu, Jinrui Zhang, Zili Wang, Hongyan Li, Lei Zhang, Jingjing Li, Fan Wang, Robert Gӧstl, Igor I. Potemkin, Dong Chen, Hongbo Zeng, Hongjie Zhang, Kai Liu*, Andreas Herrmann*, Ultra-strong bio-glue from genetically engineered polypeptides, Nat. Commun., 2021, 12, 3613.

6. Chao Ma#, Jingjin Dong#, Marco Viviani#, Isotta Tulini, Nicola Pontillo, Sourav Maity, Yu Zhou, Wouter H. Roos, Kai Liu*, Andreas Herrmann*, Giuseppe Portale*, De Novo Rational Design of a Freestanding, Supercharged Polypeptide, Proton-Conducting Membrane. Science Advances, 2020, 6(29): eabc0810.

7. Chao Ma#, Juanjuan Su#, Yao Sun#, Yang Feng, Nolan Shen, Bo Li, Yingxia Liang, Xintong Yang, Hui Wu, Hongjie Zhang, Andreas Herrmann*, Rudolph E. Tanzi, Kai Liu*, Can Zhang*, Significant Upregulation of Alzheimer's Beta-Amyloid Levels in a Living System Induced by Extracellular Elastin Polypeptides. Angew. Chem. Int. Ed., 2019, 58(51): 18703-18709.

8. Chao Ma#, Bo Li#, Jinrui Zhang#, Yao Sun, Jingjing Li, Hangcheng Zhou, Jianlei Shen, Rui Gu, Jiangchao Qian, Chunhai Fan, Hongjie Zhang, Kai Liu*, Significantly Improving the Bioefficacy for Rheumatoid Arthritis with Supramolecular Nanoformulations. Adv. Mater., 2021: e2100098.

9. Chao Ma, Anke Malessa, Arnold J. Boersma, Kai Liu, Andreas Herrmann*, Supercharged Proteins and Polypeptides. Adv. Mater., 2020: e1905309.

10. Chao Ma, Bo Li, Baiqi Shao, Baiheng Wu, Dong Chen, Juanjuan Su*, Hongjie Zhang, Kai Liu*, Anisotropic Protein Organofibers Encoded with Extraordinary Mechanical Behavior for Cellular Mechanobiology Applications. Angew. Chem. Int. Ed., 2020, 59(48): 21481-21487.

11. Chao Ma#, Juanjuan Su#, Bo Li, Andreas Herrmann, Hongjie Zhang, Kai Liu*, Solvent-Free Plasticity and Programmable Mechanical Behaviors of Engineered Proteins. Adv. Mater., 2020: e1907697.

12. Jing Sun#, Chao Ma#, Sourav Maity#, Fan Wang, Yu Zhou, Giuseppe Portale, Robert Gostl, Wouter H. Roos, Hongjie Zhang, Kai Liu*, Andreas Herrmann*, Reversibly Photo-Modulating Mechanical Stiffness and Toughness of Bioengineered Protein Fibers. Angew. Chem. Int. Ed., 2021, 60(6): 3222-3228.

13. Lei Zhang#, Chao Ma#, Jing Sun, Baiqi Shao, Giuseppe Portale, Dong Chen, Kai Liu*, Andreas Herrmann*, Genetically Engineered Supercharged Polypeptide Fluids: Fast and Persistent Self-Ordering Induced by Touch. Angew. Chem. Int. Ed., 2018, 57(23): 6878-6882.

14. Huige Yang#, Chao Ma#, Kaiyong Li, Kai Liu, Mark Loznik, Rosalie Teeuwen, Jan C. M. Van Hest, Xin Zhou*, Andreas Herrmann*, Jianjun Wang*, Tuning Ice Nucleation with Supercharged Polypeptides. Adv. Mater., 2016, 28(25): 5008-5012.

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