张奇伟

 

 

张奇伟 

清华大学   信息科学与技术国家实验室/医学院

首批千人计划教授

长江学者讲座教授

 

教育经历

1977-1981 中科大近代力学系, 学士

1981-1987 Rutgers U, 统计物理博士

1987-1991 美国NYU Courant Inst.,应用数学博士后

1991-1996 美国冷泉港实验室基因组研究Fellow

1996-1998 美国冷泉港实验室,Assistant Staff

1999-2001 美国冷泉港实验室,Associate Professor

2002-2010 美国冷泉港实验室, Full Professor

2009-至今 清华大学信息学院与医学院双聘教授,生命学院兼职教授,博导,清华信息国家实验室合成与系统生物实验室主任

2010-至今 美国UT Dallas,Cecil H. and Ida Green Distinguished Chair Professor, Director of Center for Systems Biology

 

 研究方向

 

计算生物学与生物信息学,合成生物与系统生物学,特别是利用高通量组学技术和高性能计算机模拟,研究细胞发育、分化、凋亡的基因调控和代谢网络,以及它们在癌症等疾病、生物能源、和环境中的应用。

 

担任职务

 

合成与系统生物学中心共同主任

清华信息国家实验室合成与系统生物实验室主任

 

所获荣誉

 

2005年获得教育部长江学者讲座教授称号

2009年成为清华大学首批5位千人教授之一

 

代表论文

 

He C, Zhang MQ, Wang X (2015) MICC: an R package for identifying chromatin interactions from ChIA-PET data. Bioinformatics, in press.

Guo Y, Xu Q, Canzio D, Shou J, Li J, Gorkin DU, Jung I, Wu H, Zhai Y, Tang Y, Lu Y, Wu Y, Jia Z, Li W, Zhang MQ, Ren B, Krainer AR, Maniatis T, Wu Q (2015) CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell 162:900-10. PMID: 26276636.

Ehrhardt K, Guinn MT, Quarton T, Zhang MQ, Bleris L (2015) Reconfigurable hybrid interface for molecular marker diagnostics and in-situ reporting. Biosens Bioelectron. 74:744-750. PMID: 26210472

Hu L, Di C, Kai M, Yang Y-C, Li Y, Qiu Y, Hu X, Yip KY, Zhang MQ, Lu ZJ (2015) A common set of distinct features that characterize noncoding RNAs across multiple species. NAR. 43:104-14. PMID: 25505163, PMCID: PMC4288202.

Orozco LD, Marco Morselli M, Rubbi L, Guo W, Go J, Shi H, Lopez D, Furlotte NA, Bennett BJ, Charles R. Farber CR, Ghazalpour A, Zhang MQ, Bahous R, Rozen R, Lusis AJ, Pellegrini M (2015) Epigenome-Wide Association of Liver Methylation Patterns and Complex Metabolic Traits in Mice. Cell Metabolism, 21:905-17. PMID: 26039453, PMCID: PMC4454894.

Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen Y-G, Zhang MQ*, Tao Q*, Wu W* (2015) Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. JBC, 290:17239-49. PMID: 26013826, PMCID: PMC4498063.

Akerman M, Fregoso O, Das S, Ruse C, Jensen MA, Pappin DL, Zhang MQ, Krainer A. (2015) Differential connectivity of splicing activators and repressors to the human spliceosome. Genome Biol. 16:119. PMID: 26047612, PMCID: PMC4502471.

Wang T, Xiao G; Chu Y, Zhang MQ, Corey D, Xie Y (2015) Design and bioinformatics analysis of genome-wide CLIP experiments. NAR, PMID:25958398.

Huo W, Adams HM, Zhang MQ, Palmer KL (2015) Genome modification in Enterococcus faecalisOG1RF assessed by bisulfite sequencing and single molecule real time sequencing. J. Bacteriology 197:1939-51. PMID:25825433.

Yuan Y, Liu B, Xie P, Zhang MQ, Li Y, Zhen X, Wang X (2015) Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit. PNAS, 112:3158-63. PMID:25713348.

Raodmap Epigenomics Consortium (2015) Integrative analysis of 111 reference human epigenomes. Nature, 518:317-30. PMID:25693563

Leung D, Jung I, Rajagopal N, Schmitt A, Selvaraj S, Lee AY, Yen CA, Lin S, Lin Y, Qiu Y, Xie W, Yue F, Hariharan M, Ray P, Kuan S, Edsall L, Yang H, Chi NC, Zhang MQ, Ecker JR, Ren B (2015) Integrative analysis of haplotype-resolved epigenomes across human tissues. Nature, 518:350-4. PMID:25693566

Li L, Tang J, Zhang B, Yang W, Liugao M, Wang R, Tan Y, Fan J, Chang Y, Fu J, Jiang F, Chen C, Yang Y, Gu J, Wu D, Guo L, Cao D, Li H, Cao G, Wu M, Zhang MQ, Chen L, Wang H (2015) Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4. Gut 64:156-67. PMID: 24572141.

 

联系方式

 

清华大学信息科学与技术国家实验室

北京100084,中国

电话:+86-10-62792696

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